Primary Information | |
---|---|
BoMiProt ID | Bomi4669 |
Protein Name | Cholesterol side-chain cleavage enzyme, mitochondrial/CYPXIA1/Cholesterol desmolase/Cytochrome P450 11A1/Cytochrome P450(scc) |
Organism | Bos taurus |
Uniprot ID | P00189 |
Milk Fraction | Whey |
Ref Sequence ID | NP_788817.1 |
Aminoacid Length | 520 |
Molecular Weight | 60333 |
FASTA Sequence | Download |
Gene Name | CYP11A1 |
Gene ID | 338048 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | catalyzes the first step of steroidogenesis where cholesterol is converted to pregnenolone. |
Biochemical Properties | catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
CATH | Matched CATH superfamily 1.10.630.10 |
Predicted Disorder Regions | 33-47 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 1SCC,2ASA,3MZS, |
Bibliography | Slominski AT, Li W, Kim TK, Semak I, Wang J, Zjawiony JK, Tuckey RC. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. 2015 Jul;151:25-37. doi: 10.1016/j.jsbmb.2014.11.010. Epub 2014 Nov 13. PMID: 25448732; PMCID: PMC4757911. |