Search by BoMiProt ID - Bomi4669

Primary Information

BoMiProt ID Bomi4669
Protein Name Cholesterol side-chain cleavage enzyme, mitochondrial/CYPXIA1/Cholesterol desmolase/Cytochrome P450 11A1/Cytochrome P450(scc)
Organism Bos taurus
Uniprot IDP00189
Milk FractionWhey
Ref Sequence ID NP_788817.1
Aminoacid Length 520
Molecular Weight 60333
FASTA Sequence Download
Gene Name CYP11A1
Gene ID 338048
Protein Existence Status reviewed

Secondary Information

Protein Function catalyzes the first step of steroidogenesis where cholesterol is converted to pregnenolone.
Biochemical Properties catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
CATH Matched CATH superfamily
Predicted Disorder Regions 33-47
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Slominski AT, Li W, Kim TK, Semak I, Wang J, Zjawiony JK, Tuckey RC. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. 2015 Jul;151:25-37. doi: 10.1016/j.jsbmb.2014.11.010. Epub 2014 Nov 13. PMID: 25448732; PMCID: PMC4757911.