Search by BoMiProt ID - Bomi4651

Primary Information

BoMiProt ID Bomi4651
Protein Name Chitinase-3-like protein 1/39 kDa whey protein/Cartilage glycoprotein 39/Chitinase-like protein 1
Organism Bos taurus
Uniprot IDP30922
Milk FractionExosomes
Ref Sequence ID NP_001073688.1
Aminoacid Length 383
Molecular Weight 43032
FASTA Sequence Download
Gene Name CHI3L1
Gene ID 286869
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Mammary secretions collected during the non-lactating period.
Protein Function It plays a major role in tissue injury, inflammation, tissue repair, and remodeling responses.
Biochemical Properties CHI3L1 consisted of an (β/α)8-barrel domain with a second domain composed of six antiparallel β-strands, with one α-helix (α + β) domain inserted after strand β7. It binds to chitin, but lacks enzymatic activity.A 43-residue carbohydrate-binding cleft was found exposed at the C-terminal side of the β-strands in the (β/α)8 barrel.This structure suggests that CHI3L1 acts as a sensor to turn on innate defenses and regulates inflammatory responses as a consequence of infection, which can also contribute to tumorigenesis.
PTMs Disulfide bond formation,N-Linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a/b)
Fold : TIM beta/alpha-barrel
Superfamily : (Trans)glycosidases
Family : Type II chitinase
Domain Name : 1OWQ A:1-239, A:308-361

Class : Alpha and beta proteins (a+b)
Fold : FKBP-like
Superfamily : Chitinase insertion domain
Family : Chitinase insertion domain
Domain Name : 1OWQ A:240-307

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Overexpression of CHI3L1 has been observed in a number of inflammatory conditions including asthma, sepsis, diabetes, cirrhosis, preeclampsia, rheumatoid arthritis, and coronary artery disease.
Bibliography 1.Zhao T, Su Z, Li Y, Zhang X, You Q. Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduct Target Ther. 2020 Sep 14;5(1):201. doi: 10.1038/s41392-020-00303-7. PMID: 32929074; PMCID: PMC7490424. 2.Kumar J, Ethayathulla AS, Srivastava DB, Sharma S, Singh SB, Srinivasan A, Yadav MP, Singh TP. Structure of a bovine secretory signalling glycoprotein (SPC-40) at 2.1 Angstrom resolution. Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):953-63. doi: 10.1107/S0907444906020427. Epub 2006 Aug 19. PMID: 16929095. 3.Bara I, et al. Role of YKL-40 in bronchial smooth muscle remodeling in asthma. Am. J. Respir. Crit. Care Med. 2012;185:715–722. 4.Berres ML, et al. A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection. J. Hepatol. 2009;50:370–376. 4. Furuhashi K, et al. Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis. Respir. Med. 2010;104:1204–1210. 5.Seol HJ, et al. Serum levels of YKL-40 and interleukin-18 and their relationship to disease severity in patients with preeclampsia. J. Reprod. Immunol. 2009;79:183–187.