Search by BoMiProt ID - Bomi4606

Primary Information

BoMiProt ID Bomi4606
Protein Name Cellular retinoic acid-binding protein 1
Organism Bos taurus
Uniprot IDP62964
Milk FractionWhey
Ref Sequence ID NP_851371.1
Aminoacid Length 137
Molecular Weight 15592
FASTA Sequence Download
Gene Name CRABP1
Gene ID 282201
Protein Existence Status reviewed

Secondary Information

Protein Function physiological role against the development of obesity.inhibits adipocyte hypertrophy
Biochemical Properties bovine CRABP comprises 136 amino acid residues. 3 cysteine residues . The molecular weight, 15,460, calculated from the sequence is close to the apparent molecular weight, 16,300, on SDS-polyacrylam- ide gel electrophoresis.A "β-clam" motif built up from10-strands.The CrabpI gene is driven by a housekeeping promoter, but can be regulated by numerous factors, including thyroid hormones and RA, which engage a specific chromatin-remodeling complex containing either TRAP220 or RIP140 as coactivator and corepressor.The chromatin-remodeling complex binds the DR4 element in the CrabpI gene promoter.
PTMs No covalently modified amino acids were detected during the sequencing
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All beta proteins
Fold : Lipocalins
Superfamily : Lipocalins
Family : Fatty acid binding protein-like
Domain Name : 2CBR A:1-136

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments CRABPI functions mainly in the cytoplasm to modulate intracellular RA availability/concentration and to engage other signaling components such as ERK activity.
Bibliography Lin YW, Park SW, Lin YL, Burton FH, Wei LN. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. Int J Obes (Lond). 2020 Feb;44(2):466-474. doi: 10.1038/s41366-019-0379-z. Epub 2019 Jun 4. Erratum in: Int J Obes (Lond). 2019 Nov;43(11):2347. PMID: 31164723; PMCID: PMC6891142.