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Primary Information | |
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| BoMiProt ID | Bomi4606 |
| Protein Name | Cellular retinoic acid-binding protein 1 |
| Organism | Bos taurus |
| Uniprot ID | P62964 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_851371.1 |
| Aminoacid Length | 137 |
| Molecular Weight | 15592 |
| FASTA Sequence | Download |
| Gene Name | CRABP1 |
| Gene ID | 282201 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | physiological role against the development of obesity.inhibits adipocyte hypertrophy |
| Biochemical Properties | bovine CRABP comprises 136 amino acid residues. 3 cysteine residues . The molecular weight, 15,460, calculated from the sequence is close to the apparent molecular weight, 16,300, on SDS-polyacrylam- ide gel electrophoresis.A "β-clam" motif built up from10-strands.The CrabpI gene is driven by a housekeeping promoter, but can be regulated by numerous factors, including thyroid hormones and RA, which engage a specific chromatin-remodeling complex containing either TRAP220 or RIP140 as coactivator and corepressor.The chromatin-remodeling complex binds the DR4 element in the CrabpI gene promoter. |
| PTMs | No covalently modified amino acids were detected during the sequencing |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
| SCOP | Class : All beta proteins Fold : Lipocalins Superfamily : Lipocalins Family : Fatty acid binding protein-like Domain Name : 2CBR A:1-136 |
| CATH | Matched CATH superfamily 2.40.128.20 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 2CBR, |
| Additional Comments | CRABPI functions mainly in the cytoplasm to modulate intracellular RA availability/concentration and to engage other signaling components such as ERK activity. |
| Bibliography | Lin YW, Park SW, Lin YL, Burton FH, Wei LN. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. Int J Obes (Lond). 2020 Feb;44(2):466-474. doi: 10.1038/s41366-019-0379-z. Epub 2019 Jun 4. Erratum in: Int J Obes (Lond). 2019 Nov;43(11):2347. PMID: 31164723; PMCID: PMC6891142. |