Primary Information | |
---|---|
BoMiProt ID | Bomi4606 |
Protein Name | Cellular retinoic acid-binding protein 1 |
Organism | Bos taurus |
Uniprot ID | P62964 |
Milk Fraction | Whey |
Ref Sequence ID | NP_851371.1 |
Aminoacid Length | 137 |
Molecular Weight | 15592 |
FASTA Sequence | Download |
Gene Name | CRABP1 |
Gene ID | 282201 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | physiological role against the development of obesity.inhibits adipocyte hypertrophy |
Biochemical Properties | bovine CRABP comprises 136 amino acid residues. 3 cysteine residues . The molecular weight, 15,460, calculated from the sequence is close to the apparent molecular weight, 16,300, on SDS-polyacrylam- ide gel electrophoresis.A "β-clam" motif built up from10-strands.The CrabpI gene is driven by a housekeeping promoter, but can be regulated by numerous factors, including thyroid hormones and RA, which engage a specific chromatin-remodeling complex containing either TRAP220 or RIP140 as coactivator and corepressor.The chromatin-remodeling complex binds the DR4 element in the CrabpI gene promoter. |
PTMs | No covalently modified amino acids were detected during the sequencing |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
SCOP | Class : All beta proteins Fold : Lipocalins Superfamily : Lipocalins Family : Fatty acid binding protein-like Domain Name : 2CBR A:1-136 |
CATH | Matched CATH superfamily 2.40.128.20 |
Predicted Disorder Regions | NA |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 2CBR, |
Additional Comments | CRABPI functions mainly in the cytoplasm to modulate intracellular RA availability/concentration and to engage other signaling components such as ERK activity. |
Bibliography | Lin YW, Park SW, Lin YL, Burton FH, Wei LN. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. Int J Obes (Lond). 2020 Feb;44(2):466-474. doi: 10.1038/s41366-019-0379-z. Epub 2019 Jun 4. Erratum in: Int J Obes (Lond). 2019 Nov;43(11):2347. PMID: 31164723; PMCID: PMC6891142. |