Primary Information |
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| BoMiProt ID | Bomi4599 |
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| Protein Name | Cell division cycle protein 27 homolog |
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| Organism | Bos taurus |
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| Uniprot ID | A7Z061 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001098898.1 |
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| Aminoacid Length | 825 |
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| Molecular Weight | 91870 |
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| FASTA Sequence |
Download |
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| Gene Name | CDC27 |
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| Gene ID | 540660 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Component of the anaphase promoting complex/cyclosome (APC/C), |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7Z061|CDC27_BOVIN Cell division cycle protein 27 homolog OS=Bos taurus OX=9913 GN=CDC27 PE=2 SV=1
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCL
PNSCTTLVSNHSLSHRQPETVLTET*205PQDT*209IELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDT*244VPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPS*291PGDGSYLQN
YTNTSSVIDVPPT*313GAPSKKSVARIGQTGTKSVFSQSGNS*339REVTPILVAQTQSSGPQTSTT
PQVLSPT*367ITSPPNALPRRSS*389RLFTSDS*387STTKENSKKLKMKFPPKIPNRKTKSKTNKGGIT
QPNINDS*427LEIT*431KLDSS*436IIS*439EGKISTIT*447PQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIY
STTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPN
YAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQ
KALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKY
KSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAI
DKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAES*822DEF
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| Predicted Disorder Regions | 196-209, 244-412, 793-824 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Casein kinase II (CKII) is involved in the phosphorylation of Cdc27 in response to TGF-β signaling.Phosphorylation on Ser-427 and Thr-447 occurs specifically during mitosis. |
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| Bibliography | Zhang L, Fujita T, Wu G, Xiao X, Wan Y. Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling. J Biol Chem. 2011 Mar 25;286(12):10041-50. doi: 10.1074/jbc.M110.205518. Epub 2011 Jan 5. PMID: 21209074; PMCID: PMC3060455. |
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