Primary Information |
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| BoMiProt ID | Bomi4578 |
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| Protein Name | CDGSH iron-sulfur domain-containing protein 1/MitoNEET |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBU2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029229.1 |
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| Aminoacid Length | 106 |
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| Molecular Weight | 11983 |
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| FASTA Sequence |
Download |
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| Gene Name | CISD1 |
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| Gene ID | 531444 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | testis |
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| Protein Function | CDGSH iron sulfur domain-containing protein 1 (CISD-1) belongs to the CISD protein family that is evolutionary conserved across different species. In mammals, CISD-1 protein has been implicated in diseases such as cancers and diabetes. |
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| Biochemical Properties | This protein possesses one CDGSH domain close to the N-terminus and a C-terminal transmembrane domain, an organization analogous to human CISD-1 and CISD-2 . |
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| PTMs | N6-Acetylation at Lys, Isopeptide bond formation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-3, 40-47, 81-106 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH;(12-34) |
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| Significance of PTMs | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. |
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| Bibliography | 1.Hsiung KC, Liu KY, Tsai TF, Yoshina S, Mitani S, Chin-Ming Tan B, Lo SJ. Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans. Biomed J. 2020 Feb;43(1):32-43. doi: 10.1016/j.bj.2019.07.009. Epub 2020 Feb 27. PMID: 32200954; PMCID: PMC7090286. |
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