Search by BoMiProt ID - Bomi4578

Primary Information

BoMiProt ID Bomi4578
Protein Name CDGSH iron-sulfur domain-containing protein 1/MitoNEET
Organism Bos taurus
Uniprot IDQ3ZBU2
Milk FractionWhey
Ref Sequence ID NP_001029229.1
Aminoacid Length 106
Molecular Weight 11983
FASTA Sequence Download
Gene Name CISD1
Gene ID 531444
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells testis
Protein Function CDGSH iron sulfur domain-containing protein 1 (CISD-1) belongs to the CISD protein family that is evolutionary conserved across different species. In mammals, CISD-1 protein has been implicated in diseases such as cancers and diabetes. 
Biochemical Properties This protein possesses one CDGSH domain close to the N-terminus and a C-terminal transmembrane domain, an organization analogous to human CISD-1 and CISD-2 .
PTMs N6-Acetylation at Lys, Isopeptide bond formation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-3, 40-47, 81-106
DisProt Annotation
TM Helix Prediction 1TMH;(12-34)
Significance of PTMs Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. 
Bibliography 1.Hsiung KC, Liu KY, Tsai TF, Yoshina S, Mitani S, Chin-Ming Tan B, Lo SJ. Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans. Biomed J. 2020 Feb;43(1):32-43. doi: 10.1016/ Epub 2020 Feb 27. PMID: 32200954; PMCID: PMC7090286.