Search by BoMiProt ID - Bomi4543

Primary Information

BoMiProt ID Bomi4543
Protein Name CCAAT/enhancer binding protein delta
Organism Bos taurus
Uniprot ID O02756
Milk FractionWhey,MFGM
Ref Sequence ID NP_776692.2
Aminoacid Length 256
Molecular Weight 27137
FASTA Sequence Download
Gene Name CEBPD
Gene ID 281678
Protein Existence Status reviewed

Secondary Information

Protein Function transcriptional repressor of α-synuclein.Elevated α-synuclein levels in Lewy bodies nad intracellular accumulation are associated with increased risk for Parkinson's disease.The expression level of CEBPD is typically low in most cells at normal physiological conditions but is rapidly induced by external stimuli including glucocorticoids, insulin and growth factors, e.g., epidermal growth factor.CEBPD has been suggested to be activated by inflammatory factors, such as interleukin-6 (IL-6) [17,18], lipopolysaccharides (LPS) [19-25], interferon-α, interferon-γ (IFN-γ) [26], tumor necrosis factor-α (TNFα) [27-30], prostaglandin E2 (PGE2) [31-33] and interleukin-1β.
Biochemical Properties zip transcription factor.diverse N-termini, a highly conserved (>90% identity) basic leucine zipper domain and a basic domain for dimerization and DNA binding at their C termini.
PTMs Acetylation on Ser, Ubl conjugation
Predicted Disorder Regions 5 disordered segments; (4-48), (82-126), (131-212), (218-223), (230-256)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments C/EBPδ as an important repressor of SNCA transcription and suggests that reduced C/EBPδ neuronal levels could be a pathogenic factor in Parkinson's disease and other synucleinopathies and C/EBPδ activity a potential pharmacological target for these neurological disorders.CEBPD mediates in IFN-γ- and IL-1β- induced anti-apoptosis and anti-inflammation in pancreatic β-cells.Target genes is pentraxin-3
Bibliography Valente T, Dentesano G, Ezquerra M, Fernandez-Santiago R, Martinez-Martin J, Gallastegui E, Domuro C, Compta Y, Martí MJ, Bachs O, Márquez-Kisinousky L, Straccia M, Solà C, Saura J. CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein. Cell Death Differ. 2020 Feb;27(2):509-524. doi: 10.1038/s41418-019-0368-8. Epub 2019 Jun 17. PMID: 31209363; PMCID: PMC7206087.