Primary Information |
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BoMiProt ID | Bomi4543 |
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Protein Name | CCAAT/enhancer binding protein delta |
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Organism | Bos taurus |
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Uniprot ID | O02756 |
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Milk Fraction | Whey,MFGM |
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Ref Sequence ID | NP_776692.2 |
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Aminoacid Length | 256 |
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Molecular Weight | 27137 |
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FASTA Sequence |
Download |
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Gene Name | CEBPD |
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Gene ID | 281678 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | transcriptional repressor of α-synuclein.Elevated α-synuclein levels in Lewy bodies nad intracellular accumulation are associated with increased risk for Parkinson's disease.The expression level of CEBPD is typically low in most cells at normal physiological conditions but is rapidly induced by external stimuli including glucocorticoids, insulin and growth factors, e.g., epidermal growth factor.CEBPD has been suggested to be activated by inflammatory factors, such as interleukin-6 (IL-6) [17,18], lipopolysaccharides (LPS) [19-25], interferon-α, interferon-γ (IFN-γ) [26], tumor necrosis factor-α (TNFα) [27-30], prostaglandin E2 (PGE2) [31-33] and interleukin-1β. |
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Biochemical Properties | zip transcription factor.diverse N-termini, a highly conserved (>90% identity) basic leucine zipper domain and a basic domain for dimerization and DNA binding at their C termini. |
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PTMs | Acetylation on Ser, Ubl conjugation |
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Predicted Disorder Regions | 5 disordered segments; (4-48), (82-126), (131-212), (218-223), (230-256) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | C/EBPδ as an important repressor of SNCA transcription and suggests that reduced C/EBPδ neuronal levels could be a pathogenic factor in Parkinson's disease and other synucleinopathies and C/EBPδ activity a potential pharmacological target for these neurological disorders.CEBPD mediates in IFN-γ- and IL-1β- induced anti-apoptosis and anti-inflammation in pancreatic β-cells.Target genes is pentraxin-3 |
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Bibliography | Valente T, Dentesano G, Ezquerra M, Fernandez-Santiago R, Martinez-Martin J, Gallastegui E, Domuro C, Compta Y, Martí MJ, Bachs O, Márquez-Kisinousky L, Straccia M, Solà C, Saura J. CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein. Cell Death Differ. 2020 Feb;27(2):509-524. doi: 10.1038/s41418-019-0368-8. Epub 2019 Jun 17. PMID: 31209363; PMCID: PMC7206087. |