Primary Information |
---|
BoMiProt ID | Bomi4539 |
---|
Protein Name | C-C motif chemokine 2 |
---|
Organism | Bos taurus |
---|
Uniprot ID | P28291 |
---|
Milk Fraction | Whey |
---|
Ref Sequence ID | NP_776431.1 |
---|
Aminoacid Length | 99 |
---|
Molecular Weight | 11114 |
---|
FASTA Sequence |
Download |
---|
Gene Name | CCL2 |
---|
Gene ID | 281043 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Protein Function | Acts as a ligand for C-C chemokine receptor CCR2.Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions .Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils.Plays an important role in mediating peripheral nerve injury-induced neuropathic pain.Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
---|
Significance in milk | CCL2 is a novel target for improving the quantity and quality of milk from cows through stimulation of proliferation on mammary epithelial cells and attenuation of LPS-induced inflammatory responses. |
---|
PTMs | Disulfide bond,Glycosylation |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
---|
Predicted Disorder Regions | 3 disordered segment; (1-4), (11-16), (91-99) |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |