Search by BoMiProt ID - Bomi4539

Primary Information

BoMiProt ID Bomi4539
Protein Name C-C motif chemokine 2
Organism Bos taurus
Uniprot IDP28291
Milk FractionWhey
Ref Sequence ID NP_776431.1
Aminoacid Length 99
Molecular Weight 11114
FASTA Sequence Download
Gene Name CCL2
Gene ID 281043
Protein Existence Status reviewed

Secondary Information

Protein Function Acts as a ligand for C-C chemokine receptor CCR2.Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions .Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils.Plays an important role in mediating peripheral nerve injury-induced neuropathic pain.Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
Significance in milk CCL2 is a novel target for improving the quantity and quality of milk from cows through stimulation of proliferation on mammary epithelial cells and attenuation of LPS-induced inflammatory responses.
PTMs Disulfide bond,Glycosylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 3 disordered segment; (1-4), (11-16), (91-99)
DisProt Annotation
TM Helix Prediction No TM helices