Primary Information
BoMiProt ID	Bomi4493
Protein Name	Casein kinase II subunit alpha/CK II alpha
Organism	Bos taurus
Uniprot ID	P68399
Milk Fraction	whey
Ref Sequence ID	NP_777060.2
Aminoacid Length	391
Molecular Weight	45144
FASTA Sequence	Download
Gene Name	CSNK2A1/CK2A1
Gene ID	282419
Protein Existence Status	Reviewed
Secondary Information
Protein Function	It regulates different functions such as cell cycle progression, apoptosis and transcription, and viral infection.
Significance in milk	Phosphorylation of milk proteins
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|P68399|CSK21_BOVIN Casein kinase II subunit alpha OS=Bos taurus OX=9913 GN=CSNK2A1 PE=1 SV=1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGST*344PVSSANMMSGISSVPT*360 PS*362PLGPLAGS*370PVIAAANPLGMPVPAAAGAQQ
Predicted Disorder Regions	6-9, 332-391
DisProt Annotation
TM Helix Prediction	no TM helices
Significance of PTMs	Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments
Bibliography	Litchfield, D. W., Lozeman, F. J., Piening, C., Sommercorn, J., Takio, K., Walsh, K. A., & Krebs, E. G. (1990). Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides. The Journal of biological chemistry, 265(13), 7638–7644.