Primary Information |
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| BoMiProt ID | Bomi4490 |
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| Protein Name | Cartilage oligomeric matrix protein |
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| Organism | Bos taurus |
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| Uniprot ID | P35445 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 756 |
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| Molecular Weight | 82362 |
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| FASTA Sequence |
Download |
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| Gene Name | COMP |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | large pentameric glycoprotein. collagen secretion and fibrillogenesis, chondrocyte proliferation and mechanical strength of tendons |
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| Biochemical Properties | each monomeric arm contains an N-terminal domain, four type 2 (T2) epidermal growth factor-like repeats, seven type 3 (T3) repeats and a C-terminal globular domain (CTD). The T2 and T3 repeats and CTD bind calcium ions critical to correct protein folding.The T3 repeats contain highly conserved aspartic acid rich motifs, usually containing five aspartic acid residues per motif, with each motif wrapping around two calcium ions. The CTD is a lectin-like-β sandwich domain composed of 15 β-strands and contain four calcium binding sites. |
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| PTMs | Disulfide bond, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P35445|COMP_BOVIN Cartilage oligomeric matrix protein OS=Bos taurus OX=9913 GN=COMP PE=1 SV=2
MVLAAARVLLLTLAALGASGQGQMPLGGDLGPQMLRELQETNAALQDVRDLLRQQVKEIT
FLKNTVMECDACGMQPARTPKLTVRPLSQCSPGFCFPGVACTETANGARCGPCPEGFTGN*120
GSHCADVNECTAHPCFPRVRCINTSPGFRCEACPPGFSGPTHEGVGLAFAKANKQVCTDI
NECETGQHNCVPNSVCVNTVGSFQCGPCQPGFVGDQASGCRRRPQRFCPDGTPSPCHEKA
DCVLERDGSRSCVCAVGWAGNGLICGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQE
DVDQDGIGDACDPDADGDGVLNEKDNCPLVRNPDQRNTDGDKWGDACDNCRSQKNDDQKD
TDKDGRGDACDDDIDGDRIRNPVDNCPKVPNSDQKDTDGDGVGDACDNCPQKSNADQRDV
DHDFVGDACDSDQDQDGDGHQDSKDNCPTVPNSAQQDSDHDGQGDACDDDDDNDGVPDSR
DNCRLVPNPGQEDMDRDGVGDACQGDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDP
EGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIF
GYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTA
SQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVILDTTMRGGR
LGVFCFSQENIIWANLRYRCN*741DTIPEDYEAQRLLQA
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| Predicted Disorder Regions | 337-516 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Posey KL, Coustry F, Hecht JT. Cartilage oligomeric matrix protein: COMPopathies and beyond. Matrix Biol. 2018 Oct;71-72:161-173. doi: 10.1016/j.matbio.2018.02.023. Epub 2018 Mar 9. PMID: 29530484; PMCID: PMC6129439. |
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