Search by BoMiProt ID - Bomi4490


Primary Information

BoMiProt ID Bomi4490
Protein Name Cartilage oligomeric matrix protein
Organism Bos taurus
Uniprot IDP35445
Milk FractionWhey
Aminoacid Length 756
Molecular Weight 82362
FASTA Sequence Download
Gene Name COMP
Protein Existence Status reviewed

Secondary Information

Protein Function large pentameric glycoprotein. collagen secretion and fibrillogenesis, chondrocyte proliferation and mechanical strength of tendons
Biochemical Properties each monomeric arm contains an N-terminal domain, four type 2 (T2) epidermal growth factor-like repeats, seven type 3 (T3) repeats and a C-terminal globular domain (CTD). The T2 and T3 repeats and CTD bind calcium ions critical to correct protein folding.The T3 repeats contain highly conserved aspartic acid rich motifs, usually containing five aspartic acid residues per motif, with each motif wrapping around two calcium ions. The CTD is a lectin-like-β sandwich domain composed of 15 β-strands and contain four calcium binding sites.
PTMs Disulfide bond, Glycosylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P35445|COMP_BOVIN Cartilage oligomeric matrix protein OS=Bos taurus OX=9913 GN=COMP PE=1 SV=2 MVLAAARVLLLTLAALGASGQGQMPLGGDLGPQMLRELQETNAALQDVRDLLRQQVKEIT FLKNTVMECDACGMQPARTPKLTVRPLSQCSPGFCFPGVACTETANGARCGPCPEGFTGN*120 GSHCADVNECTAHPCFPRVRCINTSPGFRCEACPPGFSGPTHEGVGLAFAKANKQVCTDI NECETGQHNCVPNSVCVNTVGSFQCGPCQPGFVGDQASGCRRRPQRFCPDGTPSPCHEKA DCVLERDGSRSCVCAVGWAGNGLICGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQE DVDQDGIGDACDPDADGDGVLNEKDNCPLVRNPDQRNTDGDKWGDACDNCRSQKNDDQKD TDKDGRGDACDDDIDGDRIRNPVDNCPKVPNSDQKDTDGDGVGDACDNCPQKSNADQRDV DHDFVGDACDSDQDQDGDGHQDSKDNCPTVPNSAQQDSDHDGQGDACDDDDDNDGVPDSR DNCRLVPNPGQEDMDRDGVGDACQGDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDP EGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIF GYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTA SQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVILDTTMRGGR LGVFCFSQENIIWANLRYRCN*741DTIPEDYEAQRLLQA
Predicted Disorder Regions 337-516
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Posey KL, Coustry F, Hecht JT. Cartilage oligomeric matrix protein: COMPopathies and beyond. Matrix Biol. 2018 Oct;71-72:161-173. doi: 10.1016/j.matbio.2018.02.023. Epub 2018 Mar 9. PMID: 29530484; PMCID: PMC6129439.