Primary Information |
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| BoMiProt ID | Bomi4465 |
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| Protein Name | Caprin-1/Cytoplasmic activation- and proliferation-associated protein 1/RNA granule protein 105 |
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| Organism | Bos taurus |
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| Uniprot ID | Q1LZB6 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 708 |
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| Molecular Weight | 78328 |
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| FASTA Sequence |
Download |
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| Gene Name | CAPRIN1/RNG105 |
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| Gene ID | 535571 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Caprin-1 is also involved in the regulation of synaptic plasticity.It is is localized in the neuronal RNA granules in dendrites of hippocampal and neocortical pyramidal neurons.Caprin-1 also regulates interferon (IFN)-mediated antiviral innate immune response. |
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| Biochemical Properties | contain two highly conserved homologous regions (HR1 and HR2) and C-terminal RGG motifs.a less conserved E-rich region is present between HR1 and HR2.Caprin-1 residues 231-245 were reported to be required for interaction with FMRP,scaffording proteins. 231-245 is located within the 5 helix of the dimerization domain. The negatively charged putative protein binding groove formed by homodimerization of Caprin-1 and the E-rich region C-terminal to the dimerization domain interact with the JEV core protein. |
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| PTMs | Acetylation, Glycosylation, Methylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q1LZB6|CAPR1_BOVIN Caprin-1 OS=Bos taurus OX=9913 GN=CAPRIN1 PE=2 SV=1
MPSATSHSGS*10GSKSSGPPPPSGSSGNEAGAGAAAPASQHPMTGTGAVQTEAMKQILGVID
KKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRS*113FMALSQD
IQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEE
LSLLDEFYKLADPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQ
SNYFDSTHNHQNGLCEEEEAASAPTVEDQAAEAEPEPVEEYTEQNEVESTEYVNRQFMAE
TQFSSGEKEQVDDWTVETVEVVNSLQQQPQAAS*333PSVPEPHS*341LTPVAQADPLVRRQRVQDL
MAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPAQNMDIPQLVCPPVHSESRLAQPNQ
VSVQPEATQVPLVSSTSEGYTASQPLYQPSHATDQRPQKEPIDQIQATISLNTDQTTASS
SLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQ
ASYNQSFSSQPHQVEQTELQQEQLQTVVGTYHGSQDQPHQVTGNHQQPPQQNTGFPRSNQ
PYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSTNTPNSGYTQSQFSAPRD
YSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
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| Predicted Disorder Regions | 1-25, 253-349, 362-382, 400-479, 496-503, 530-595 |
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| DisProt Annotation | |
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| TM Helix Prediction | 9TMHs; (899-917), (928-950), (959-977), (984-1006), (1010-1032),(1098-1116), (1128-1150), (1157-1175), and (1243-1265) |
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| Bibliography | Wu Y, Zhu J, Huang X, Zhou X, Du Z. Crystal structure of a dimerization domain of human Caprin-2: similar overall dimeric fold but different molecular surface properties to that of human Caprin-1. J Biomol Struct Dyn. 2019 Sep;37(15):3968-3975. doi: 10.1080/07391102.2018.1532817. Epub 2019 Jan 11. PMID: 30304999; PMCID: PMC6459735. |
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