Primary Information |
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| BoMiProt ID | Bomi4423 |
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| Protein Name | Calmegin |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SYT6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029377.1 |
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| Aminoacid Length | 606 |
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| Molecular Weight | 69515 |
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| FASTA Sequence |
Download |
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| Gene Name | CLGN |
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| Gene ID | 504256 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. |
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| Biochemical Properties | Calmegin is a testis-specific Ca(2+)-binding protein that is homologous to calnexin. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3SYT6|CLGN_BOVIN Calmegin OS=Bos taurus OX=9913 GN=CLGN PE=2 SV=1
MRFQGFWLCLGLLFISVNAEFMDDSVEMEDFDENSEETDELSSEIKYKTPQPVGEVYFTE
TFDSGRLAGWVLSKAKKDDIDAEISIYDGRWEIEELKENRIPGDRGLVLKSRAKHHAISA
VLAKPFIFADKPLVVQYEVNFQDGIDCGGAYIKLLADTDGLNLENFYDKTSYTIMFGPDK
CGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKRFFTDRKTHLYTLVMNPDDTFEVLID
QIVVNKGSLLEDVVPPINPPKEIEDPTDEKPDDWDERAKIPDASAVKPEDWDESEPPQIV
DSSAVKPDGWLDNEPEFIPDPNAEKPFDWNEDMDGEWEAPHISNPACRIGCGEWSPPMID
NPKYKGIWRPPMIDNPNYQGIWSPRKIPNPDYFEDNHPFLLTSFRALGLELWSMTSDIYF
DNFIICSEKEVADRWAADGWGMKILIENANEPSIFKQLMSATEQRPWLWFIYLLTAALPI
ALIGSFCWPRKVKKKYEDVAFEKLDICKPQTKGALEQEVKEEKAALEKPVDLEEEKKQSD
GEIVEKEEEGEPEEKS*556EEEIEIIEGQEEGNKS*572NKS*575GS*577EDEMKEADES*587TGS*590GDGPIKS*597VRKRRVRKE
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| Predicted Disorder Regions | 26-54, 261-337, 500-511, 527-606 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (466-488) |
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| Additional Comments | The immunoreactivity is completely absent in the calmegin-deficient mutant mouse testis. |
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| Bibliography | 1.Yoshinaga K, Tanii I, Toshimori K. Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis. Arch Histol Cytol. 1999 Aug;62(3):283-93. doi: 10.1679/aohc.62.283. PMID: 10495883. 2.Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M. Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. Dev Biol. 2001 Dec 1;240(1):254-61. doi: 10.1006/dbio.2001.0462. PMID: 11784061. |
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