Search by BoMiProt ID - Bomi4421

Primary Information

BoMiProt ID Bomi4421
Protein Name Calcium-transporting ATPase type 2C member 1/ATPase 2C1/ATP-dependent Ca(2+) pump PMR1/Ca(2+)/Mn(2+)-ATPase 2C1/Secretory pathway Ca(2+)-transporting ATPase type 1/SPCA1
Organism Bos taurus
Uniprot IDP57709
Milk Fractionwhey
Ref Sequence ID NP_786979.1
Aminoacid Length 953
Molecular Weight 104780
FASTA Sequence Download
Gene Name ATP2C1/SPCA
Gene ID 327663
Protein Existence Status Reviewed

Secondary Information

Protein Function ATP-driven pump that supplies the Golgi apparatus with Ca2+ and Mn2+ ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway
Biochemical Properties ATP + Ca2+(in) + H2O = ADP + Ca2+(out) + H+ + phosphate
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 8 TMHs; (116-134), (138-156), (303-321), (333-355), (809-827), (842-860), (880-898), (907-929)
Bibliography Brown, J. M., & García-García, M. J. (2018). Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development (Cambridge, England), 145(19), dev170019.