Primary Information |
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| BoMiProt ID | Bomi4414 |
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| Protein Name | Calcium-responsive transcription factor/Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q58CW6 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001027465.1 |
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| Aminoacid Length | 703 |
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| Molecular Weight | 78135 |
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| FASTA Sequence |
Download |
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| Gene Name | CARF/ALS2CR8 |
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| Gene ID | 509072 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | regulates neuronal activity-dependent expression of BDNF |
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| Biochemical Properties | Extensive analysis of the CaRF sequence has shown that it has no significant homology to any known proteins in the GenBank database and no domains that would identify it as a member of a family of transcription factors. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-151, 246-249, 524-538, 573-588, 614-635 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | CaRF is a neuronal nuclear protein with discrete DNA binding and transcriptional activation domains that can activatetranscription from the CaRE1 element in BDNF promoter III. |
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| Bibliography | 1.Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383-95. doi: 10.1016/s0896-6273(01)00561-x. PMID: 11832226. |
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