Primary Information |
|---|
| BoMiProt ID | Bomi4412 |
|---|
| Protein Name | Calcium-binding and coiled-coil domain-containing protein 1 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q2KJ21 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001039900.1 |
|---|
| Aminoacid Length | 680 |
|---|
| Molecular Weight | 75661 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | CALCOCO1 |
|---|
| Gene ID | 538675 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | CALCOCO1 as a novel ER-phagy receptor for the degradation of the tubular ER in response to proteotoxic and nutrient stress.Involved in positive regulation of gene expression and positive regulation oftranscription, DNA-templated. |
|---|
| Biochemical Properties | CALCOCO1 is a homomeric protein that binds directly to ATG8 proteins via LIR- and UDS-interacting region (UIR) motifs acting co-dependently. CALCOCO1-mediated ER-phagy requires interaction with VAMP-associated proteins VAPA and VAPB on the ER membranes via a conserved FFAT-like motif. |
|---|
| PTMs | Phosphorylation at Ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJ21|CACO1_BOVIN Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=2 SV=1
MEES*4SLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRD
YHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFRE
PRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQ
VQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTI
SEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLEL
QEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAA
LLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVE
AEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALR
VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSE
DESPEDMRLPPYSLCESGDSGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEA
EDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLTEASTGGPATPPWKECPIC
KERFPVHTQTHTYTHTHTHA |
|---|
| Predicted Disorder Regions | 528-617 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | no TM helices |
|---|
| Additional Comments | Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA-574-5p to modulate CALCOCO1 expression |
|---|
| Bibliography | 1.Yu G, Xiong D, Liu Z, Li Y, Chen K, Tang H. Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA-574-5p to modulate CALCOCO1 expression. J Cell Biochem. 2019 Oct;120(10):17258-17272. doi: 10.1002/jcb.28988. Epub 2019 May 19. PMID: 31104316. 2.Nthiga TM, Kumar Shrestha B, Sjøttem E, Bruun JA, Bowitz Larsen K, Bhujabal Z, Lamark T, Johansen T. CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy. EMBO J. 2020 Aug 3;39(15):e103649. doi: 10.15252/embj.2019103649. Epub 2020 Jun 11. PMID: 32525583; PMCID: PMC7396842. |
|---|
