Primary Information |
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| BoMiProt ID | Bomi4406 |
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| Protein Name | Calcium/calmodulin-dependent protein kinase type II subunit beta/CaM kinase II subunit beta/CaMK-II subunit beta |
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| Organism | Bos taurus |
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| Uniprot ID | Q3MHJ9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001030434.1 |
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| Aminoacid Length | 542 |
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| Molecular Weight | 60482 |
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| FASTA Sequence |
Download |
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| Gene Name | CAMK2B |
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| Gene ID | 525416 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | widely expressed in brain.isoform of multisubunit enzyme serine/threonine kinase CaMKII.involved in dendritic spine and synapse formation, neuronal plasticity and regulation of F-actin stabilization at activated synapses |
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| PTMs | autophosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3MHJ9|KCC2B_BOVIN Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Bos taurus OX=9913 GN=CAMK2B PE=2 SV=1
MATTVTCTRFTDEYQLY*17EDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRIMAHEALKHPWVCQRSTVASMMHRQET*287VECLKKFNARRKL
KGAILT*306T*307MLATRNFSVGRQTTAPATMSTAASGATMGLVEQAKSLLNKKADGVKPQTNSTK
NSAAATS*367PKGTLPPAALEPQTTVIHNPVDGIKESSDSTHTTIEDEDTKARKQEIIKITEQ
LIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILN
PHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAP
LQ
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| Predicted Disorder Regions | 323-407, 507-516 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | In response to transient influxes of Ca2+ and in the presence of calmodulin and ATP, CaMKII subunits undergo rapid autophosphorylation at characteristic residues (threonine 286 in CaMKIIα) through intramolecular and/or intermolecular interactions, which enable CaMKII to be active independent of Ca2+/calmodulin |
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| Bibliography | Liu XB, Murray KD. Neuronal excitability and calcium/calmodulin-dependent protein kinase type II: location, location, location. Epilepsia. 2012 Jun;53 Suppl 1:45-52. doi: 10.1111/j.1528-1167.2012.03474.x. PMID: 22612808. |
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