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Primary Information | |
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| BoMiProt ID | Bomi4391 |
| Protein Name | Calcineurin subunit B type 1/Protein phosphatase 2B regulatory subunit 1/Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
| Organism | Bos taurus |
| Uniprot ID | P63099 |
| Milk Fraction | Exosomes |
| Ref Sequence ID | NP_777008.1 |
| Aminoacid Length | 170 |
| Molecular Weight | 19300 |
| FASTA Sequence | Download |
| Gene Name | PPP3R1 |
| Gene ID | 282321 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | occipital lobe |
| Protein Function | The calcineurin (CN) B subunit (CNB) is the regulatory subunit of CN, which is the only serine/threonine-specific protein phosphatase regulated by Ca2+/CaM. |
| PTMs | Lipoylation, N-Myristoylation at Gly, Phosphorylation at Ser |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P63099|CANB1_BOVIN Calcineurin subunit B type 1 OS=Bos taurus OX=9913 GN=PPP3R1 PE=1 SV=2 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGY*106ISNGELFQVLKMMV GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV |
| CATH | Matched CATH superfamily 1.10.238.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1TCO, |
| Additional Comments | Overexpression of calcineurin B subunit (CnB) enhances the oncogenic potential of HEK293 cells |
| Bibliography | 1.Li N, Zhang Z, Zhang W, Wei Q. Calcineurin B subunit interacts with proteasome subunit alpha type 7 and represses hypoxia-inducible factor-1α activity via the proteasome pathway. Biochem Biophys Res Commun. 2011 Feb 18;405(3):468-72. doi: 10.1016/j.bbrc.2011.01.055. Epub 2011 Jan 20. PMID: 21256111. 2.Aitken A, Klee CB, Cohen P. The structure of the B subunit of calcineurin. Eur J Biochem. 1984 Mar 15;139(3):663-71. doi: 10.1111/j.1432-1033.1984.tb08055.x. PMID: 6321184. 3.Yan-Li Wang; Ying Wang; Li Tong; Qun Wei (2008). Overexpression of calcineurin B subunit (CnB) enhances the oncogenic potential of HEK293 cells. , 99(6), 1100–1108. doi:10.1111/j.1349-7006.2008.00799.x. |