Search by BoMiProt ID - Bomi4314


Primary Information

BoMiProt ID Bomi4314
Protein Name Brevican core protein
Organism Bos taurus
Uniprot IDQ28062
Milk FractionWhey
Aminoacid Length 912
Molecular Weight 99554
FASTA Sequence Download
Gene Name BCAN
Protein Existence Status reviewed

Secondary Information

Protein Function A diverse set of proteoglycans is expressed in the developing and adult brain. These proteoglycans may play a major functional role in cell-cell and cell-matrix interactions in the brain. 
Biochemical Properties Brevican is a member of the aggrecan/versican family of proteoglycans, containing a hyaluronic acid-binding domain in its N-terminus and a lectin-like domain in its C-terminus. 
PTMs Disulfide bond formation,N-Linked Glycosylation at Asn, Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q28062|PGCB_BOVIN Brevican core protein OS=Bos taurus OX=9913 GN=BCAN PE=1 SV=1 MAPLFLPLLATLVLAWIPVALADALEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH YLRPSPSRRAAQGSPRVKWTFLSGGREAEVLVARGLRVKVSEAYRFRVALPAYPASLTDV SLVLSELRPN*130DSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFAGAQEACA RIGARIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV DPDDLYDVYCYAEELNGELFLGAPPDKLTLEEARTYCQERGAKIATTGQLYAAWDGGLDR CSSGWLSDGSVRYPIVTPSQRCGGGLPGVKTLFLFPN*337QTGFPNKHSRFNVYCFRDSAQPS AIPEAANPASHLASDALEAIVTVTETLEELKLPQEAVESESRGAIYSIPIIEDGGGGS*418ST PEDPAEAPRTLLEFETQSIVPPLGSSEEEGKVLEQEEKYRGEEEKEEEEEEEEVEDEALW AWPSELSSLDPEAPLPTEPVPEESLTQASPPVRAALQPGVSPPPYDEPEAPRPPRVLGPP TKTLPTPREGNLASPPPSTLVGAREIEEETGGPELSGAPRGESEETGSSEDAPSLLPATR APGDTRDLETPSEENSRRTVPAGTSVRAQPVLPTDSASRGGVAVAPSSGDCVPSPCHNGG TCLEEEEGVRCLCLPGYGGDLCDVGLHFCSPGWDAFQGACYKHFSARRSWEEAENKCRMY GAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFL SGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAEVFGRPRLRYEVDTV LRYRCREGLTQRNLPLIRCQENGRWGLPQISCVPRRPARALRPVEAQEGRPWRLVGHWKA RLNPSPNPAPGP
Predicted Disorder Regions 361-645
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments Brevican has the smallest core protein among this family and is one of the most abundant chondroitin sulfate proteoglycans in the adult brain. Expression of brevican is highly specific in the brain and increases as the brain develops. 
Bibliography 1.Yamaguchi Y. Brevican: a major proteoglycan in adult brain. Perspect Dev Neurobiol. 1996;3(4):307-17. PMID: 9117262. 2.