Primary Information |
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BoMiProt ID | Bomi4314 |
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Protein Name | Brevican core protein |
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Organism | Bos taurus |
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Uniprot ID | Q28062 |
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Milk Fraction | Whey |
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Aminoacid Length | 912 |
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Molecular Weight | 99554 |
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FASTA Sequence |
Download |
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Gene Name | BCAN |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | A diverse set of proteoglycans is expressed in the developing and adult brain. These proteoglycans may play a major functional role in cell-cell and cell-matrix interactions in the brain. |
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Biochemical Properties | Brevican is a member of the aggrecan/versican family of proteoglycans, containing a hyaluronic acid-binding domain in its N-terminus and a lectin-like domain in its C-terminus. |
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PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn, Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q28062|PGCB_BOVIN Brevican core protein OS=Bos taurus OX=9913 GN=BCAN PE=1 SV=1
MAPLFLPLLATLVLAWIPVALADALEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH
YLRPSPSRRAAQGSPRVKWTFLSGGREAEVLVARGLRVKVSEAYRFRVALPAYPASLTDV
SLVLSELRPN*130DSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFAGAQEACA
RIGARIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV
DPDDLYDVYCYAEELNGELFLGAPPDKLTLEEARTYCQERGAKIATTGQLYAAWDGGLDR
CSSGWLSDGSVRYPIVTPSQRCGGGLPGVKTLFLFPN*337QTGFPNKHSRFNVYCFRDSAQPS
AIPEAANPASHLASDALEAIVTVTETLEELKLPQEAVESESRGAIYSIPIIEDGGGGS*418ST
PEDPAEAPRTLLEFETQSIVPPLGSSEEEGKVLEQEEKYRGEEEKEEEEEEEEVEDEALW
AWPSELSSLDPEAPLPTEPVPEESLTQASPPVRAALQPGVSPPPYDEPEAPRPPRVLGPP
TKTLPTPREGNLASPPPSTLVGAREIEEETGGPELSGAPRGESEETGSSEDAPSLLPATR
APGDTRDLETPSEENSRRTVPAGTSVRAQPVLPTDSASRGGVAVAPSSGDCVPSPCHNGG
TCLEEEEGVRCLCLPGYGGDLCDVGLHFCSPGWDAFQGACYKHFSARRSWEEAENKCRMY
GAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFL
SGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAEVFGRPRLRYEVDTV
LRYRCREGLTQRNLPLIRCQENGRWGLPQISCVPRRPARALRPVEAQEGRPWRLVGHWKA
RLNPSPNPAPGP
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Predicted Disorder Regions | 361-645 |
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DisProt Annotation | |
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TM Helix Prediction | no TM helices |
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Additional Comments | Brevican has the smallest core protein among this family and is one of the most abundant chondroitin sulfate proteoglycans in the adult brain. Expression of brevican is highly specific in the brain and increases as the brain develops. |
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Bibliography | 1.Yamaguchi Y. Brevican: a major proteoglycan in adult brain. Perspect Dev Neurobiol. 1996;3(4):307-17. PMID: 9117262. 2. |