Search by BoMiProt ID - Bomi4293

Primary Information

BoMiProt ID Bomi4293
Protein Name Brain acid soluble protein 1/22 kDa neuronal tissue-enriched acidic protein/Neuronal axonal membrane protein NAP-22
Organism Bos taurus
Uniprot IDP80724
Milk FractionWhey,MFGM
Ref Sequence ID NP_777205.1
Aminoacid Length 227
Molecular Weight 23011
FASTA Sequence Download
Gene Name BASP1/NAP22
Gene ID 286842
Protein Existence Status reviewed

Secondary Information

Protein Function BASP1 strongly interferes with v‐Myc‐induced oncogenicity and displays properties of a tumor suppressor.brain acid-soluble protein 1 gene (BASP1) is specifically downregulated by the v-myc oncogene and that ectopic BASP1 expression inhibits v-myc-induced cell transformation.
Biochemical Properties The 11-amino acid effector domain of the BASP1 protein interacts with the calcium sensor calmodulin (CaM) and is mainly responsible for this inhibitory function. The BASP1 effector domain acts like a CaM inhibitor and interferes with MYC‐dependent oncogenesis
PTMs Isopeptide bond, Lipidation, Myristoylation, Phosphorylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1 disordered segment; (1-227)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments BASP1 belongs to the GAP43/myristoylated alanine‐rich C‐kinase substrate (MARCKS)/CAP‐23 family of myristoylated neuronal growth‐associated proteins and shares distinct biochemical properties with the other members MARCKS and growth‐associated protein 43 which also bind CaM by their basic EDs. Phosphorylation by PKC leads to disruption of the interactions of BASP1 with membrane lipids or CaM. BASP1 can then be translocated into the nucleus where it attenuates the transcriptional activity of the Wilms’ tumor suppressor protein WT1, thereby acting as a transcriptional cosuppressor, which also drives cell differentiation processes
Bibliography Hartl M, Puglisi K, Nist A, Raffeiner P, Bister K. The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin. Mol Oncol. 2020 Mar;14(3):625-644. doi: 10.1002/1878-0261.12636. Epub 2020 Jan 30. PMID: 31944520; PMCID: PMC7053243.