Search by BoMiProt ID - Bomi4273

Primary Information

BoMiProt ID Bomi4273
Protein Name Beta-synuclein/14 kDa brain-specific protein/Phosphoneuroprotein 14/PNP 14
Organism Bos taurus
Uniprot IDP33567
Milk FractionWhey
Aminoacid Length 134
Molecular Weight 14277
FASTA Sequence Download
Gene Name SNCB
Protein Existence Status reviewed

Secondary Information

Protein Function Soluble proteins in presynaptic terminals.Role in neuronal enzyme that catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and appears to play a role in cytoskeletal reorganization and/or endocytosis at the plasma membrane .
Biochemical Properties it is β-synuclein 134 aa long.α-Synuclein, β-synuclein and γ-synuclein range from 127 to 140 amino acids in length, and are 55–62% identical in sequence, with a similar domain organization.Provided with the consensus sequence KTKEGV. This positively charged region is followed by a hydrophobic middle part and a negatively charged carboxy-terminal region.Elongated helix structure.The elongated helix structure is not truly alpha-helical (3.6 amino acids per turn) but rather an α-11/3 helix, in which there are 3.67 amino acids per turn.
PTMs Phosphorylation by G-protein coupled receptor kinases (GRK),CK1, CK2 and CaM-kinase II.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1 disordered segment; (1-134)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease
Bibliography George JM. The synucleins. Genome Biol. 2002;3(1):REVIEWS3002. doi: 10.1186/gb-2001-3-1-reviews3002. Epub 2001 Dec 20. PMID: 11806835; PMCID: PMC150459.