Primary Information |
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| BoMiProt ID | Bomi4264 |
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| Protein Name | Beta-defensin 2/BNBD-2 |
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| Organism | Bos taurus |
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| Uniprot ID | P46160 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 40 |
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| Molecular Weight | 4649 |
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| FASTA Sequence |
Download |
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| Gene Name | DEFB2 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Neutrophilic granules |
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| Protein Function | human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. |
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| PTMs | Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 13-34, 37-40 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | hBD-2 expression may be a result of local inflammation or the presence of invading pathogens. |
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| Bibliography | 1.Gu J, Huang Y. β-Defensin-2 is overexpressed in human vocal cord polyps. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):901-907. doi: 10.1007/s00405-016-4270-4. Epub 2016 Sep 1. PMID: 27586391. 2.Cieślik M, Bagińska N, Górski A, Jończyk-Matysiak E. Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response. Cells. 2021 Nov 3;10(11):2991. doi: 10.3390/cells10112991. PMID: 34831214; PMCID: PMC8616480. |
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