Search by BoMiProt ID - Bomi4263

Primary Information

BoMiProt ID Bomi4263
Protein Name Beta-defensin 12
Organism Bos taurus
Uniprot IDP46170
Milk FractionWhey
Aminoacid Length 38
Molecular Weight 4106
FASTA Sequence Download
Gene Name DEFB12
Protein Existence Status Reviewed

Secondary Information

Protein Function Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
Biochemical Properties The N-terminal beta-strand and three locally well-defined tight turns form a hydrophobic face. Conserved isoleucine and glycine residues form a beta-bulge structure which initiates a beta-hairpin secondary structure motif composed of the second and C-terminal beta-strands. The beta-hairpin contains numerous charged residues and forms the cationic face of BNBD-12. The N-terminal residues were found to be disordered. The triple-stranded beta-sheet, the beta-bulge preceding the hairpin, and the cationic/hydrophobic amphiphilic character are definitive features of all defensin structures determined to date.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Small proteins
Fold : Defensin-like
Superfamily : Defensin-like
Family : Defensin
Domain Name : 1BNB A:1-38

CATH Matched CATH superfamily
Predicted Disorder Regions (11-28)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Zimmermann GR, Legault P, Selsted ME, Pardi A. Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry. 1995 Oct 17;34(41):13663-71. doi: 10.1021/bi00041a048. PMID: 7577957.