Primary Information |
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| BoMiProt ID | Bomi4252 |
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| Protein Name | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe/O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJ92 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039687.1 |
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| Aminoacid Length | 380 |
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| Molecular Weight | 41847 |
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| FASTA Sequence |
Download |
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| Gene Name | LFNG |
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| Gene ID | 516209 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Modification of Notch receptors and alters Notch signaling activity. Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. |
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| Biochemical Properties | Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. |
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| PTMs | Proteolysis,Disulfide bond, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJ92|LFNG_BOVIN Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe OS=Bos taurus OX=9913 GN=LFNG PE=2 SV=1
MLKRCGRRLLLALAGALLACLLVLTADPPPPPVPAERGRRALRSLAGPSGVATAPGLEAA
AAAAPGAPVREVHSLSEYFSLLTRSRRDVGPPPGGAPRPADGPPRPLAEPLAPRDVFIAV
KTTKKFHRARLDLLLETWISRHEEMTFIFTDGEDEALARRTGHVVNTN*168CSAAHSRQALSC
KMAVEYDRFIESGRKWFCHVDDDNYVNVRALLRLLGSYPHTQDVYLGKPSLDRPIQATER
VSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMSTAERIRLPDDCTIGYIVEA
LLGVPLVRCGLFHSHLENLQQVPASELHEQVTLSYGMFENKRNSVHIKGPFSVEADPSRF
RSVHCHLYPDTSWCPRSAIF
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| Predicted Disorder Regions | 3 disordered segments; (2-7), (30-66), (78-109) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | A soluble form may be derived from the membrane form by proteolytic processing. |
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| Bibliography | Dunwoodie SL. Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine. Biochim Biophys Acta. 2009 Feb;1792(2):100-11. doi: 10.1016/j.bbadis.2008.11.003. Epub 2008 Nov 13. PMID: 19061953. |
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