Primary Information |
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BoMiProt ID | Bomi4233 |
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Protein Name | B-cell receptor-associated protein 29/BCR-associated protein 29/Bap29 |
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Organism | Bos taurus |
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Uniprot ID | Q32KL9 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001033164.1 |
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Aminoacid Length | 240 |
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Molecular Weight | 28212 |
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FASTA Sequence |
Download |
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Gene Name | BCAP29 |
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Gene ID | 511018 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.Involved in osteoblast differentiation. Located in membrane. class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules. |
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Biochemical Properties | The N-terminal half of proteins is membrane-bound while the C-terminal half is cytoplasmic also two coiled coils is present.The second and longest of these putative coiled coils also shares weak sequence similarity with the small six-helical DED domains, suggesting that it may adopt a DED fold. vDED domain contains little α-helix at pH 7.0 while a strong increase in α-helical structure is induced at pH 4.2.BAP29 vDED is much less stable than BAP31 vDED. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | (163-240) |
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DisProt Annotation | |
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TM Helix Prediction | 3TMHs; (7-29), (44-62), (104-122) |
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Bibliography | Paquet ME, Cohen-Doyle M, Shore GC, Williams DB. Bap29/31 influences the intracellular traffic of MHC class I molecules. J Immunol. 2004 Jun 15;172(12):7548-55. doi: 10.4049/jimmunol.172.12.7548. PMID: 15187134. |