Primary Information |
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| BoMiProt ID | Bomi4198 |
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| Protein Name | Autophagy protein 5 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3MQ24 |
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| Milk Fraction | Exosomes,MFGM |
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| Ref Sequence ID | NP_001029751.2 |
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| Aminoacid Length | 275 |
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| Molecular Weight | 32431 |
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| FASTA Sequence |
Download |
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| Gene Name | ATG5 |
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| Gene ID | 532686 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | ATG5 is recognized as a key player needed for the formation of autophagosomes which is also important because of its potential contribution to apoptosis. |
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| PTMs | N-acetylation at Methionine, Isopeptide bond formation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Conjugated to ATG12 which is essential for autophagy. |
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| Additional Comments | ATG5 deficiency in melanocytes interferes with oncogene-induced senescence, thus promoting melanoma tumorigenesis. |
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| Bibliography | 1.Liu H, He Z, Simon HU. Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis. J Mol Med (Berl). 2015 Feb;93(2):159-64. doi: 10.1007/s00109-014-1241-3. Epub 2014 Dec 23. PMID: 25529049. |
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