Primary Information |
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| BoMiProt ID | Bomi4163 |
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| Protein Name | ATP-dependent RNA helicase DHX30/DEAH box protein 30 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2NKY8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070003.1 |
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| Aminoacid Length | 1220 |
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| Molecular Weight | 135946 |
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| FASTA Sequence |
Download |
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| Gene Name | DHX30 |
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| Gene ID | 767607 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | highly expressed in neural cells and somites during embryogenesis ,RNA dependent helicase.Play imp role in ribosome assembly.regulates the antiviral function of the zinc-finger ZAP protein(which is antiviral protein). |
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| Biochemical Properties | DHX30 and ZAP interacted with each other via their N terminal domains. DHX30 uses ATP hydrolysis to unwind RNA secondary structures, which is required for most aspects of RNA metabolism and function |
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| PTMs | Phosphorylation on Ser15,Ubiquitination at Lys48 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2NKY8|DHX30_BOVIN ATP-dependent RNA helicase DHX30 OS=Bos taurus OX=9913 GN=DHX30 PE=2 SV=1
MATARRLMALAAGVSPRLRPLGPRAIGRQGGPRGLSTGCSRPDRTQEAAEAEAAPGEPGE
GDGSVVNASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWP
KSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWW
RPEPTMPPTSWRQLNPESIRPGGPGGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQD
SHAPLRDSRGGS*252FEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTK
TKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACNKLKSLGLVDRNNEPLTHAMYNLAS
LRELGETQRRPCTIQVPEPILRKIETFLNHYPVESSWISSELRLQGEDILPLGKDSGPLS
DPITGKPYVPLSEAEELRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVV
IAGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPTLRRN
VGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVVVDEEHERDVNTDFLLIL
LKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQ
YPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGM
HESKYLILPVHSNIPMMDQKAIFQQPPIGVRKIVLATNIAETSITINDIVHVVDSGLHKE
ERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMAPFQVPEILRT
PLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRL
AHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGS
DHLAFVRAVSGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGK
PSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGN
ILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGR
RATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALPPCVQEEHGQLLAL
LAELLRGPCGSFDVRKTADD
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Ye P, Liu S, Zhu Y, Chen G, Gao G. DEXH-Box protein DHX30 is required for optimal function of the zinc-finger antiviral protein. Protein Cell. 2010 Oct;1(10):956-64. doi: 10.1007/s13238-010-0117-8. Epub 2010 Nov 9. PMID: 21204022; PMCID: PMC4875121. |
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