Search by BoMiProt ID - Bomi4157


Primary Information

BoMiProt ID Bomi4157
Protein Name ATP-dependent 6-phosphofructokinase, muscle type/6-phosphofructokinase type A/Phosphofructo-1-kinase isozyme A/Phosphohexokinase
Organism Bos taurus
Uniprot IDQ0IIG5
Milk FractionWhey
Ref Sequence ID NP_001068736.1
Aminoacid Length 779
Molecular Weight 85294
FASTA Sequence Download
Gene Name PFKM
Gene ID 506544
Protein Existence Status reviewed

Secondary Information

Protein Function Catalyzes the first committing step of glycolysis.the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP.
Biochemical Properties Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.requires Mg2+ as cofactor.Bovine PFK molecular weight of the bovine native PFK was estimated to 400,000.heterotetramer composed of three kinds of subunit with molecular weights of 92,000 (C-type), 88,000 (M-type) and 86,000 (L-type).
PTMs Acetylation, Glycosylation, Hydroxylation, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q0IIG5|PFKAM_BOVIN ATP-dependent 6-phosphofructokinase, muscle type OS=Bos taurus OX=9913 GN=PFKM PE=2 SV=1 MTHEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIYTGARVFFVHEGYQGLVDG GDNIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGS LTGADTFRSEWS*132DLLSDLQKSGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSA LHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEE HLCRRLSETRNRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQR GGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTRA MDERRFDEALKLRGRS*376FMNNWEVYKLLAHVRPPKSKSGSHTVAVMNVGAPAAGMNAAVRS TVRIGLIQGNRMLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQI SANITKFNIQGLVIIGGFEAYTGGLELMEGRKQYDELCIPFVVIPATVS*529NNVPGSDFSVG ADTALNTICMTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEDPFT IRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGH MQQGGS*666PTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANSPDSGCVLGMRKRALVFQ PVTELKEQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSEHAHLEHISRKRS*774GEANV
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Fukushima E, Sugiya H. Purification and characterization of phosphofructokinase in bovine parotid gland. Int J Biochem. 1992 Aug;24(8):1307-14. doi: 10.1016/0020-711x(92)90206-g. PMID: 1386580.