Primary Information |
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| BoMiProt ID | Bomi4155 |
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| Protein Name | ATP-binding cassette sub-family F member 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJA2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039601.1 |
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| Aminoacid Length | 625 |
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| Molecular Weight | 71475 |
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| FASTA Sequence |
Download |
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| Gene Name | ABCF2 |
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| Gene ID | 513061 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | cytoprotective and antiapoptotic role.a binding partner of ACTN4,regulation of cell volume and anion channels in epithelial cells. |
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| Biochemical Properties | functional antioxidant response element (ARE) in its promoter region.consists of NH2 actin binding domain,spectrin like repeat domain,EF Hand type calcium binding domain at C terminal.NH2 terminal is imp for binding to ACTN4.contain NBDs and no putative transmembrane domain. |
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| PTMs | Acetylation on Lys, Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJA2|ABCF2_BOVIN ATP-binding cassette sub-family F member 2 OS=Bos taurus OX=9913 GN=ABCF2 PE=2 SV=1
MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAITEPQVAEERNEEANGRETTEVDLLTK
ELEDFEMKKAAARAVTGVLASHPNSTDAHIINLSLTFHGQELLSDTKLELNSGRRYGLIG
LNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAER
LAHEDAECEKLLELYERLEELDADKAEMRASRILHGLGFT*220PAMQRKKLKDFSGGWRMRVA
LARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHM
HNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQS
KEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEF
GIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS
PLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVS*514PIRNLSDGQKCRVCLAWLAWQNPHML
FLDEPTNHLDIETIDALADAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDI
LAYKEHLKSKLVGEEPQPTRRTHNV
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| Predicted Disorder Regions | (1-81) |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | reported to contribute to chemoresistance in clear cell ovarian cancer. |
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| Bibliography | Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y. Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells. J Cell Physiol. 2012 Oct;227(10):3498-510. doi: 10.1002/jcp.24050. PMID: 22252987. |
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