Primary Information |
---|
BoMiProt ID | Bomi4155 |
---|
Protein Name | ATP-binding cassette sub-family F member 2 |
---|
Organism | Bos taurus |
---|
Uniprot ID | Q2KJA2 |
---|
Milk Fraction | Whey |
---|
Ref Sequence ID | NP_001039601.1 |
---|
Aminoacid Length | 625 |
---|
Molecular Weight | 71475 |
---|
FASTA Sequence |
Download |
---|
Gene Name | ABCF2 |
---|
Gene ID | 513061 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Protein Function | cytoprotective and antiapoptotic role.a binding partner of ACTN4,regulation of cell volume and anion channels in epithelial cells. |
---|
Biochemical Properties | functional antioxidant response element (ARE) in its promoter region.consists of NH2 actin binding domain,spectrin like repeat domain,EF Hand type calcium binding domain at C terminal.NH2 terminal is imp for binding to ACTN4.contain NBDs and no putative transmembrane domain. |
---|
PTMs | Acetylation on Lys, Phosphorylation on Ser |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJA2|ABCF2_BOVIN ATP-binding cassette sub-family F member 2 OS=Bos taurus OX=9913 GN=ABCF2 PE=2 SV=1
MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAITEPQVAEERNEEANGRETTEVDLLTK
ELEDFEMKKAAARAVTGVLASHPNSTDAHIINLSLTFHGQELLSDTKLELNSGRRYGLIG
LNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAER
LAHEDAECEKLLELYERLEELDADKAEMRASRILHGLGFT*220PAMQRKKLKDFSGGWRMRVA
LARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHM
HNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQS
KEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEF
GIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS
PLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVS*514PIRNLSDGQKCRVCLAWLAWQNPHML
FLDEPTNHLDIETIDALADAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDI
LAYKEHLKSKLVGEEPQPTRRTHNV
|
---|
Predicted Disorder Regions | (1-81) |
---|
DisProt Annotation | |
---|
TM Helix Prediction | no TM helices |
---|
Significance of PTMs | reported to contribute to chemoresistance in clear cell ovarian cancer. |
---|
Bibliography | Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y. Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells. J Cell Physiol. 2012 Oct;227(10):3498-510. doi: 10.1002/jcp.24050. PMID: 22252987. |