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Primary Information | |
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| BoMiProt ID | Bomi4142 |
| Protein Name | ATP synthase subunit O, mitochondrial/ATP synthase peripheral stalk subunit OSCP/Oligomycin sensitivity conferral protein/ OSCP |
| Organism | Bos taurus |
| Uniprot ID | P13621 |
| Milk Fraction | whey |
| Ref Sequence ID | NP_776669.1 |
| Aminoacid Length | 213 |
| Molecular Weight | 23320 |
| FASTA Sequence | Download |
| Gene Name | ATP5PO/ATP5O |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Protein Function | Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain |
| PTMs | Acetylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
| CATH | Matched CATH superfamily 1.10.520.20 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 |
| PDB ID | 2BO5,2JMX,2WSS,4B2Q,5ARA,5ARE,5ARH,5ARI,5FIJ,5FIK,5FIL,6YY0,6Z1R,6Z1U,6ZIQ,6ZIT,6ZIU,6ZPO,6ZQM,6ZQN, 7AJB,7AJC,7AJD,7AJE,7AJF,7AJG,7AJH,7AJI,7AJJ, |
| Bibliography | Walker, J. E., Gay, N. J., Powell, S. J., Kostina, M., & Dyer, M. R. (1987). ATP synthase from bovine mitochondria: sequences of imported precursors of oligomycin sensitivity conferral protein, factor 6, and adenosinetriphosphatase inhibitor protein. Biochemistry, 26(26), 8613–8619. https://doi.org/10.1021/bi00400a018 |