Search by BoMiProt ID - Bomi4140

Primary Information

BoMiProt ID Bomi4140
Protein Name ATP synthase subunit delta, mitochondrial/ATP synthase F1 subunit delta/F-ATPase delta subunit
Organism Bos taurus
Uniprot IDP05630
Milk FractionWhey
Ref Sequence ID NP_788843.1
Aminoacid Length 168
Molecular Weight 17612
FASTA Sequence Download
Gene Name ATP5F1D
Gene ID 338081
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  laryngeal cartilage
Protein Function F1Fo-ATP synthase δ subunit is required for lethal C. albicans infection. 
Biochemical Properties  F1Fo-ATP synthase consists of two major domains, a globular F1 catalytic domain (the α3β3 domain) and a membrane-bound Fo proton-translocating domain (the ab2c8-12 domain), which are linked by a central stalk containing the γ, ε and δ subunits. The δ and ε subunits interact with a Rossmann fold in the γ subunit, forming a foot that interacts with the c-ring and couples the transmembrane proton motive force to catalyse in the α3β3 domain, in which the δ subunit plays a key role in the mechanical coupling of the F1 domain to the Fo domain.
PTMs N6-acetylation at Lysine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Long alpha-hairpin
Superfamily : Epsilon subunit of F1F0-ATP synthase C-terminal domain
Family : Epsilon subunit of F1F0-ATP synthase C-terminal domain
Domain Name : 2V7Q H:102-145

CATH Matched CATH superfamily
Predicted Disorder Regions (1-28)
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1E79, 1H8E, 2CK3, 2JDI, 2V7Q, 2W6H, 2W6I, 2W6J, 2WSS, 2XND, 4ASU, 4YXW, 5ARA, 5ARE, 5ARH, 5ARI, 5FIJ,5FIK, 5FIL, 6YY0, 6Z1R, 6Z1U, 6ZG7, 6ZG8, 6ZIK, 6ZPO, 6ZQM, 6ZQN, 7AJB, 7AJC, 7AJD, 7AJE, 7AJF, 7AJG, 7AJH, 7AJI, 7AJJ,
Bibliography 1.Li S, Zhao Y, Zhang Y, Zhang Y, Zhang Z, Tang C, Weng L, Chen X, Zhang G, Zhang H. The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans. Nat Commun. 2021 Oct 15;12(1):6041. doi: 10.1038/s41467-021-26313-9. PMID: 34654833; PMCID: PMC8519961. 2. Song J, Pfanner N, Becker T. Assembling the mitochondrial ATP synthase. Proc. Natl Acad. Sci. USA. 2018;115:2850–2852. doi: 10.1073/pnas.1801697115. 3.Duvezin-Caubet S, Caron M, Giraud MF, Velours J, di Rago JP. The two rotor components of yeast mitochondrial ATP synthase are mechanically coupled by subunit delta. Proc. Natl Acad. Sci. USA. 2003;100:13235–13240. doi: 10.1073/pnas.2135169100. 4.Gibbons C, Montgomery MG, Leslie AG, Walker JE. The structure of the central stalk in bovine F(1)-ATPase at 2.4 A resolution. Nat. Struct. Biol. 2000;7:1055–1061. doi: 10.1038/80981. 5.Fillingame RH. Getting to the bottom of the F1-ATPase. Nat. Struct. Biol. 2000;7:1002–1004. doi: 10.1038/80902. 6.Duvezin-Caubet S, et al. A “petite obligate” mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase. J. Biol. Chem. 2006;281:16305–16313. doi: 10.1074/jbc.M513805200.