Primary Information |
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| BoMiProt ID | Bomi4002 |
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| Protein Name | Arginase-1/Liver-type arginase/Type I arginase |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJ64 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039619.1 |
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| Aminoacid Length | 322 |
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| Molecular Weight | 35009 |
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| FASTA Sequence |
Download |
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| Gene Name | ARG1 |
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| Gene ID | 513608 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | liver |
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| Protein Function | Arginase-1 is an enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJ64|ARGI1_BOVIN Arginase-1 OS=Bos taurus OX=9913 GN=ARG1 PE=2 SV=1
MSSKPQS*7IGVIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKELECDVKDYGDLSFADNLD
DS*62PFQIVKNPRCVGKASEKLADVVAEVKKTGRISLVLGGDHSLAIGSISGHARVHPDLCV
IWVDAHTDINTPLTTKTGNLHGQPVSFLLKELKEKMPEVPGFYWVAPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDKLGIGKVMEETFS*217YLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVQGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTTVAIT
MACFGVAREGNHKPIDYLSPPK
|
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| Predicted Disorder Regions | 1-7, 18-28, 134-137, 314-322 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. |
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| Bibliography | 1.Sin YY, Baron G, Schulze A, Funk CD. Arginase-1 deficiency. J Mol Med (Berl). 2015 Dec;93(12):1287-96. doi: 10.1007/s00109-015-1354-3. Epub 2015 Oct 14. PMID: 26467175. 2.Ordóñez NG. Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation. Adv Anat Pathol. 2014 Jul;21(4):285-90. doi: 10.1097/PAP.0000000000000022. PMID: 24911253. |
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