Primary Information
BoMiProt ID	Bomi3956
Protein Name	AP2-associated protein kinase 1/Adaptor-associated kinase 1
Organism	Bos taurus
Uniprot ID	F1MH24
Milk Fraction	Whey
Aminoacid Length	957
Molecular Weight	103089
FASTA Sequence	Download
Gene Name	AAK1
Protein Existence Status	reviewed
Secondary Information
Protein Function	Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues.
PTMs	Acetylation, Methylation Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|F1MH24|AAK1_BOVIN AP2-associated protein kinase 1 OS=Bos taurus OX=9913 GN=AAK1 PE=1 SV=2 MKKFFDSRREQGGS*14GLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINSVSSGDVW EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLY*234S*235GKVIT TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK RPDIYQVSYFSFKLLKKECPIPNVQNSPIPTKLPEPVKASEAAAKKTQPKARLT*354DPIPTT ETSIAPRQRPKAGQTQPNPGILPIQPALT*389PRKRATVQPPPQAAGSSNQPGLLASVPQPKT QPPPSQPLPQSQPKQPQAPPT*441SQQPPSAPAQALPTQAQATPQHQQQLFLKQQQQQQTAPP AQQPAGTFYQQPQQQAQAPQFQAVHPAAQQPVIAQFPVVSQGSSQQQLIQNFYQQQQQQQ QLATALHQQQLLTQQAALQQKTTAAAAPQPQAQPAAAASPAPAQEPAQIQAPVRQQPKVQ TT*602PPPTIQGQKLGS*614LT*616PPS*619S*620PKAQRAGHRRILS*633DVTHSAVFGVPAS*646KST*649QLLQAAAAEASLNKSKSATTTPSGSPRASQQNVY*683NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKYPEKLGGS*727AESLIPGFQPTQGDAFAASSFSAGTAEKRKGGQTMDSSLPLLSVSDPFIPLQV PDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRL PS*842QTESVTSNRTDSLTGEDSLIDCSLLSNPTTDLLEEFAPIAISAPAHKAAEDSNLISGF DVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNS*933S*934GSSESSLPNLARSLLLVDQLIDL
Predicted Disorder Regions	12-27, 412-597, 681-694, 739-754, 829-856, 883-892, 905-940
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Bovine Genome Sequencing and Analysis Consortium, Elsik, C. G., Tellam, R. L., Worley, K. C., Gibbs, R. A., Muzny, D. M., Weinstock, G. M., Adelson, D. L., Eichler, E. E., Elnitski, L., Guigó, R., Hamernik, D. L., Kappes, S. M., Lewin, H. A., Lynn, D. J., Nicholas, F. W., Reymond, A., Rijnkels, M., Skow, L. C., Zdobnov, E. M., … Zhao, F. Q. (2009). The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (New York, N.Y.), 324(5926), 522–528. https://doi.org/10.1126/science.1169588