Primary Information |
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| BoMiProt ID | Bomi3934 |
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| Protein Name | Annexin A8/Annexin VIII |
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| Organism | Bos taurus |
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| Uniprot ID | Q95L54 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence ID | NP_776666.1 |
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| Aminoacid Length | 327 |
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| Molecular Weight | 36787 |
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| FASTA Sequence |
Download |
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| Gene Name | ANXA8 |
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| Gene ID | 281627 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | placenta |
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| Protein Function | Annexin A8 (AnxA8), a calcium-dependent phospholipid-binding protein, and canonical Wnt signalling mechanisms have both been implicated in retinal pigment epithelial (RPE) cell differentiation. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | (1-22) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Ectopic over-expression of AnxA8 led to an increase in active β-catenin and GSK-3β phosphorylation. |
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| Bibliography | 1.Lueck K, Carr AF, Yu L, Greenwood J, Moss SE. Annexin A8 regulates Wnt signaling to maintain the phenotypic plasticity of retinal pigment epithelial cells. Sci Rep. 2020 Jan 27;10(1):1256. doi: 10.1038/s41598-020-58296-w. PMID: 31988387; PMCID: PMC6985107. 2. |
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