Primary Information |
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| BoMiProt ID | Bomi389 |
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| Protein Name | Zinc transporter 7 |
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| Organism | Bos taurus |
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| Uniprot ID | A4IFD7 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001077229.1 |
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| Aminoacid Length | 376 |
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| Molecular Weight | 41745 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC30A7 |
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| Gene ID | 613851 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | ubiquitously expressed in human and mouse tissues; |
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| Protein Function | associated with the Golgi apparatus and was capable of transporting zinc from the Golgi apparatus into the cytoplasm of the cell; ZnT1 protein is involved in zinc efflux from the cell, whereas other ZnT proteins (ZnT2–7) are engaged in subcellular zinc sequestration when zinc is abundant |
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| Biochemical Properties | predicted to have six transmembrane domains with a histidine-rich loop between transmembrane domains 4 and 5; regulated at transcriptional and post-translational levels by zinc; |
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| Significance in milk | key to Zn acquisition from maternal circulation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 188-226 |
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| DisProt Annotation | |
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| TM Helix Prediction | 6TMHS ; (37-59),(69-87),(100-122),(141-159),(236-258),(264-286) |
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| Bibliography | 1. Huang, L. et al. (2005) ‘The ZIP7 Gene ( Slc39a7 ) Encodes a Zinc Transporter Involved in Zinc Homeostasis of the Golgi Apparatus’, Journal of Biological Chemistry, 280(15), pp. 15456–15463. doi: 10.1074/jbc.M412188200.
2. Kelleher, S. L. et al. (2012) ‘Mapping the zinc-transporting system in mammary cells: Molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation’, Journal of Cellular Physiology, 227(4), pp. 1761–1770. doi: 10.1002/jcp.22900. |
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