Search by BoMiProt ID - Bomi389

Primary Information

BoMiProt ID Bomi389
Protein Name Zinc transporter 7
Organism Bos taurus
Uniprot IDA4IFD7
Milk FractionExosome
Ref Sequence ID NP_001077229.1
Aminoacid Length 376
Molecular Weight 41745
FASTA Sequence Download
Gene Name SLC30A7
Gene ID 613851
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells ubiquitously expressed in human and mouse tissues;
Protein Function associated with the Golgi apparatus and was capable of transporting zinc from the Golgi apparatus into the cytoplasm of the cell; ZnT1 protein is involved in zinc efflux from the cell, whereas other ZnT proteins (ZnT2–7) are engaged in subcellular zinc sequestration when zinc is abundant
Biochemical Properties predicted to have six transmembrane domains with a histidine-rich loop between transmembrane domains 4 and 5; regulated at transcriptional and post-translational levels by zinc;
Significance in milk key to Zn acquisition from maternal circulation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 188-226
DisProt Annotation
TM Helix Prediction 6TMHS ; (37-59),(69-87),(100-122),(141-159),(236-258),(264-286)
Bibliography 1. Huang, L. et al. (2005) ‘The ZIP7 Gene ( Slc39a7 ) Encodes a Zinc Transporter Involved in Zinc Homeostasis of the Golgi Apparatus’, Journal of Biological Chemistry, 280(15), pp. 15456–15463. doi: 10.1074/jbc.M412188200.
2. Kelleher, S. L. et al. (2012) ‘Mapping the zinc-transporting system in mammary cells: Molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation’, Journal of Cellular Physiology, 227(4), pp. 1761–1770. doi: 10.1002/jcp.22900.