Search by BoMiProt ID - Bomi3883


Primary Information

BoMiProt ID Bomi3883
Protein Name Angiopoietin-4
Organism Bos taurus
Uniprot IDQ24K15
Milk FractionWhey,MFGM
Ref Sequence ID NP_001069951.1
Aminoacid Length 498
Molecular Weight 55929
FASTA Sequence Download
Gene Name ANGPT4
Gene ID 617915
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells endothelial cells
Protein Function Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Biochemical Properties Homodimer; disulfide-linked.
Significance in milk Involved in the pathological processes of energy metabolism disorders of dairy cows in the peripartum period.Peaked at parturition, and declined rapidly over the following 2 wk.
PTMs N linked Glycosylation on Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q24K15|ANGP4_BOVIN Angiopoietin-4 OS=Bos taurus OX=9913 GN=ANGPT4 PE=2 SV=1 MPSPPAMLLGGLLLIVASTTVAQRRGQEAAGRRRAHRVQHGQCSYTFVLPEPEPCPPEPE AFGGSNSLQRDSPAATLNLGDWPSQRMRQLEKMLEN*96NTQWLQKLERYIQVNLRLELAQAQ QHMVQN*126QTATMLELGTSLLTQTTAQTRKLTDVEAQVLN*158QTSRMEIQLLETSLSTNKLEKQ LLLQGHELHRLQGHNSALETRVQALETQQQAELASLSGEKERLRRLLGRQSGALAGLERT LRAASSN*247SSLLQRQQHQLLESVQRLVRVMAQGPASMRAADQLFQDCAEIQRFGAN*295ASGIY TIHVAN*306VTEPRKVFCDMEASGGGWTLIQRREN*332GSVNFQRNWKDYKQGFGNPAGEHWLGNE VVHQLTSRATYSLRVELQDWEGNEAYAQYEHFQLGSEAQLYRLSLSGYSGSAGRQSSLVL QGTN*424FSTRDADNDNCLCKCAQMLSGGWWFDACGLSNLNGIYYPARHHVRKLNGIRWHYFQ GPSYSLRTTRMMVRPSGI
Predicted Disorder Regions 1 predicted disordered segment; (31-82)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP. Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. FASEB J. 2015 Sep;29(9):3668-77. doi: 10.1096/fj.14-268920. Epub 2015 May 14. PMID: 25977256; PMCID: PMC4550378.