Primary Information |
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| BoMiProt ID | Bomi3883 |
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| Protein Name | Angiopoietin-4 |
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| Organism | Bos taurus |
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| Uniprot ID | Q24K15 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001069951.1 |
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| Aminoacid Length | 498 |
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| Molecular Weight | 55929 |
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| FASTA Sequence |
Download |
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| Gene Name | ANGPT4 |
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| Gene ID | 617915 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | endothelial cells |
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| Protein Function | Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. |
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| Biochemical Properties | Homodimer; disulfide-linked. |
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| Significance in milk | Involved in the pathological processes of energy metabolism disorders of dairy cows in the peripartum period.Peaked at parturition, and declined rapidly over the following 2 wk. |
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| PTMs | N linked Glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q24K15|ANGP4_BOVIN Angiopoietin-4 OS=Bos taurus OX=9913 GN=ANGPT4 PE=2 SV=1
MPSPPAMLLGGLLLIVASTTVAQRRGQEAAGRRRAHRVQHGQCSYTFVLPEPEPCPPEPE
AFGGSNSLQRDSPAATLNLGDWPSQRMRQLEKMLEN*96NTQWLQKLERYIQVNLRLELAQAQ
QHMVQN*126QTATMLELGTSLLTQTTAQTRKLTDVEAQVLN*158QTSRMEIQLLETSLSTNKLEKQ
LLLQGHELHRLQGHNSALETRVQALETQQQAELASLSGEKERLRRLLGRQSGALAGLERT
LRAASSN*247SSLLQRQQHQLLESVQRLVRVMAQGPASMRAADQLFQDCAEIQRFGAN*295ASGIY
TIHVAN*306VTEPRKVFCDMEASGGGWTLIQRREN*332GSVNFQRNWKDYKQGFGNPAGEHWLGNE
VVHQLTSRATYSLRVELQDWEGNEAYAQYEHFQLGSEAQLYRLSLSGYSGSAGRQSSLVL
QGTN*424FSTRDADNDNCLCKCAQMLSGGWWFDACGLSNLNGIYYPARHHVRKLNGIRWHYFQ
GPSYSLRTTRMMVRPSGI
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| Predicted Disorder Regions | 1 predicted disordered segment; (31-82) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP. Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. FASEB J. 2015 Sep;29(9):3668-77. doi: 10.1096/fj.14-268920. Epub 2015 May 14. PMID: 25977256; PMCID: PMC4550378. |
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