Primary Information |
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| BoMiProt ID | Bomi3881 |
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| Protein Name | Angiomotin-like protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | F1MRK3 |
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| Milk Fraction | whey |
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| Ref Sequence ID | XP_010799902.1 |
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| Aminoacid Length | 766 |
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| Molecular Weight | 84727 |
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| FASTA Sequence |
Download |
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| Gene Name | AMOTL2 |
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| Gene ID | 538514 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | It regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. It is essential for proper architecture of actin filaments. It also participates in angiogenesis. |
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| Biochemical Properties | It inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|F1MRK3|AMOL2_BOVIN Angiomotin-like protein 2 OS=Bos taurus OX=9913 GN=AMOTL2 PE=2 SV=3
MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQAPMEIMAP
EDSQVLQQATRQEPQGQEHQGTETHLAENGLYRLCPQPGKGEELPTY*107EEAKAHSQYYASQ
QAGPWPHVGDRDPRGPPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARTPSHMSA
SHSFPQLARNQQGPPARGAPTAEGPEPRGPPPQYPHVMLAHETTSAVTDPRYRARGSPHF
QHAEVRILQAQVPPVFLPQQQQQYQYLQQPQERHPPPHLAALSPPGVEGPASTQASLATS
GSTHLAQMETVLRENARLQRDNERLQRELESTAEKAGRIEKLESEIQRLSEAHESLTRAS
SKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQ
SYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALSNAQGRAARAEEELRKKQAYVEKV
ERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGTPGGGGGSGGTPELSAL
RLSEQLREKEEQVLALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPS
PSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKVTPGSLRPAK
SVPSIFVAAAAGTQGWQGHSSSERQVDASAQLAADRAPLEEPVAVAPLAAHAKHGSRDGS
TQTDGPPDSLEPDSLLGCSSGQRTAS*746LDS*749IATSRVQDFSDMVEILI
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| Predicted Disorder Regions | 46-84, 103-109, 183-210, 253-283, 711-732, 746-758 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway |
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| Bibliography | Han, H., Yang, B., & Wang, W. (2017). Angiomotin-like 2 interacts with and negatively regulates AKT. Oncogene, 36(32), 4662–4669. https://doi.org/10.1038/onc.2017.101 |
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