Primary Information |
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| BoMiProt ID | Bomi3880 |
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| Protein Name | Angiomotin-like protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | E1BEQ5 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 960 |
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| Molecular Weight | 106671 |
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| FASTA Sequence |
Download |
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| Gene Name | AMOTL1 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | essential for endothelial cell migration during mouse embryogenesis.component of tight junctions.TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity.Also regulates endothelial cell migration and capillary formation. |
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| PTMs | Phosphorylation on Ser and Thr,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BEQ5|AMOL1_BOVIN Angiomotin-like protein 1 OS=Bos taurus OX=9913 GN=AMOTL1 PE=3 SV=1
MLMLHVKRNTCEHTFKCPPPACYSPSSPVQILEDPSYFFPDFQLYPGRHEASLTVEANSS
IREKVVEDPLCNFHPPNFPRIPEVEMRGSEDAAAGTVLQRLIQEQLRYGTPTENMNLLAI
QHQATGSAGPAHPTNFSSTENLAQEDPQMVYQSARQEPQGQEHQVDNTVMEKQVRSAQPQ
QNNEELPTYEEAKAQSQFFRGQQPPPPPPQQQPGAVGHSYYMAGGASQKARTEGRPTVSR
ANS*243GQAHKDEALKELKQGHVRSLSERIMQLS*271LERNGAKQHLPGPGNGKAFKAGGGPS*297PAQ
PAAKMLDPRGPPPEYPFKTKQMVSPVSKTQEHGLFYSDQHPGLLHEMVKPYPAPQPARTE
VAVLRYQPPPEYGVTSRPCQLPFPSTAQQHSPVSSQNSSVSGPLHSVPLPLAPPMALGAA
PPPPAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQR
ISEAYESLVKSTTKRESLDKAMRNKLEGEIRRLHDFNRDLRDRLETANRQLSSREYDGHE
DRAAEGLYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEE
LREKQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNSQPASL
PEYNAPALMELVREKEERILALEADMTKWEQKYVEESAIRHFAMSAAATAAAERDTTIVN
HS*722RNGSYGESSLEAHIWQEEEEVVQATRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRK
DAGKTDSSSLRPARS*795VPSIAAATGTHS*807RQTSLTSSQLAEERKEEKTWKGS*830IATGLLLGKE
HNDHASTPLLPTPSAATLSPPTPGTSASSAHAKTGSKDSSTQTDKSAELFWPGVASLPTR
SRLS*904GT*906PSNS*910PVLKHPAAKGTAEKLENSPGHGKSPDHKGRVSNLLHKPEFPDGEMMEVLI
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | AMOTL1 ubiquitination induced by NEDD4L may also be involved in Lats1(large tumor suppressor kinase 1) activation. |
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| Additional Comments | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. |
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| Bibliography | 1.Zheng Y, Vertuani S, Nyström S, Audebert S, Meijer I, Tegnebratt T, Borg JP, Uhlén P, Majumdar A, Holmgren L. Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Circ Res. 2009 Jul 31;105(3):260-70. doi: 10.1161/CIRCRESAHA.109.195156. Epub 2009 Jul 9. PMID: 19590046. 2.Wei Y, Yee PP, Liu Z, Zhang L, Guo H, Zheng H, Anderson B, Gulley M, Li W. NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation. EMBO Rep. 2020 Dec 3;21(12):e50642. doi: 10.15252/embr.202050642. Epub 2020 Oct 14. PMID: 33058421; PMCID: PMC7726808. |
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