Primary Information | |
---|---|
BoMiProt ID | Bomi3846 |
Protein Name | Alpha-soluble NSF attachment protein/ SNAP-alpha/N-ethylmaleimide-sensitive factor attachment protein alpha |
Organism | Bos taurus |
Uniprot ID | P81125 |
Milk Fraction | Whey,Casein,MFGM |
Aminoacid Length | 295 |
Molecular Weight | 33225 |
FASTA Sequence | Download |
Gene Name | NAPA/SNAPA |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. intra-Golgi transport,syntaxin binding.Also it exerts antiviral effects by inhibiting the cleavage of the SARS-CoV-2 S protein and restricting SARS-CoV-2 infection. |
PTMs | Acetylation, Phosphorylation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P81125|SNAA_BOVIN Alpha-soluble NSF attachment protein OS=Bos taurus OX=9913 GN=NAPA PE=1 SV=1 MDNSGKEAEAMALLAEAERKVKNSQS*26FFS*29GLFGGSSKIEEACEIYARAANMFKMAKNWSA AGSAFCQAAHVHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIA AKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQK AIDIYEQVGTNAMDS*195PLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRE CKRIKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR |
SCOP | Class : All alpha proteins Fold : alpha-alpha superhelix Superfamily : TPR-like Family : Tetratricopeptide repeat (TPR) Domain Name : 6IP1 H:4-295 |
CATH | Matched CATH superfamily n/a |
Predicted Disorder Regions | NA |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 6IP1, |
Bibliography | 1.Wang J, Luo J, Wen Z, Wang X, Shuai L, Zhong G, Wang C, Sun Z, Chen W, Ge J, Liu R, Wang X, Bu Z. Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor. mBio. 2022 Jan 11:e0244321. doi: 10.1128/mbio.02443-21. Epub ahead of print. PMID: 35012335. 2.Whiteheart SW, Griff IC, Brunner M, Clary DO, Mayer T, Buhrow SA, Rothman JE. SNAP family of NSF attachment proteins includes a brain-specific isoform. Nature. 1993 Mar 25;362(6418):353-5. doi: 10.1038/362353a0. PMID: 8455721. |