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Primary Information | |
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| BoMiProt ID | Bomi3846 |
| Protein Name | Alpha-soluble NSF attachment protein/ SNAP-alpha/N-ethylmaleimide-sensitive factor attachment protein alpha |
| Organism | Bos taurus |
| Uniprot ID | P81125 |
| Milk Fraction | Whey,Casein,MFGM |
| Aminoacid Length | 295 |
| Molecular Weight | 33225 |
| FASTA Sequence | Download |
| Gene Name | NAPA/SNAPA |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. intra-Golgi transport,syntaxin binding.Also it exerts antiviral effects by inhibiting the cleavage of the SARS-CoV-2 S protein and restricting SARS-CoV-2 infection. |
| PTMs | Acetylation, Phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P81125|SNAA_BOVIN Alpha-soluble NSF attachment protein OS=Bos taurus OX=9913 GN=NAPA PE=1 SV=1 MDNSGKEAEAMALLAEAERKVKNSQS*26FFS*29GLFGGSSKIEEACEIYARAANMFKMAKNWSA AGSAFCQAAHVHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIA AKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQK AIDIYEQVGTNAMDS*195PLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRE CKRIKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR |
| SCOP | Class : All alpha proteins Fold : alpha-alpha superhelix Superfamily : TPR-like Family : Tetratricopeptide repeat (TPR) Domain Name : 6IP1 H:4-295 |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 6IP1, |
| Bibliography | 1.Wang J, Luo J, Wen Z, Wang X, Shuai L, Zhong G, Wang C, Sun Z, Chen W, Ge J, Liu R, Wang X, Bu Z. Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor. mBio. 2022 Jan 11:e0244321. doi: 10.1128/mbio.02443-21. Epub ahead of print. PMID: 35012335. 2.Whiteheart SW, Griff IC, Brunner M, Clary DO, Mayer T, Buhrow SA, Rothman JE. SNAP family of NSF attachment proteins includes a brain-specific isoform. Nature. 1993 Mar 25;362(6418):353-5. doi: 10.1038/362353a0. PMID: 8455721. |