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Primary Information | |
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| BoMiProt ID | Bomi3826 |
| Protein Name | Alpha-2A adrenergic receptor/Alpha-2A adrenoreceptor/Alpha-2AAR/Alpha-2D adrenergic receptor |
| Organism | Bos taurus |
| Uniprot ID | Q28838 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776924.1 |
| Aminoacid Length | 468 |
| Molecular Weight | 51123 |
| FASTA Sequence | Download |
| Gene Name | ADRA2A |
| Gene ID | 282135 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Protein Function | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Significance in milk | probably role in constriction of teat wall and to constriction of the mammary ducts |
| PTMs | Glycosylation, Palmitoylation, Disulphide bond |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q28838|ADA2A_BOVIN Alpha-2A adrenergic receptor OS=Bos taurus OX=9913 GN=ADRA2A PE=1 SV=3 MFRQEQPLAEGSFAPMGSLQPDAGN*25ASWN*29GTEAPGGGARATPYSLQVTLTLVCLAGLLML FTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS FPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKR RTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPA GPPDADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDS*348LPRRGPGATGLG APTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCP VPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | 1-37, 246-381 |
| DisProt Annotation | |
| TM Helix Prediction | 7TMHs; ( 52-74),(85-107),(122-144),(165-187),(210-232), ( 392-414), (429-447) |
| PDB ID | 6K41, |
| Bibliography | Venkataraman, V., Duda, T., & Sharma, R. K. (1997). The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor. Molecular and cellular biochemistry, 177(1-2), 113–123. https://doi.org/10.1023/a:1006830303140 |