Primary Information
BoMiProt ID	Bomi3804
Protein Name	Allograft inflammatory factor 1
Organism	Bos taurus
Uniprot ID	Q9BDK2
Milk Fraction	Exosomes
Ref Sequence ID	NP_776410.1
Aminoacid Length	147
Molecular Weight	16855
FASTA Sequence	Download
Gene Name	AIF1
Gene ID	280989
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	spleen
Protein Function	Allograft inflammatory factor-1 (AIF-1) is a 17 kDa calcium-binding protein produced by monocytes, macrophages, and lymphocytes; its synthesis is induced by INF-γ.
PTMs	Phosphorylation at Serine,N-acetylation at Serine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q9BDK2|AIF1_BOVIN Allograft inflammatory factor 1 OS=Bos taurus OX=9913 GN=AIF1 PE=2 SV=1 MSETRDLQGGKAFGLRKAQQEERINEINQQFLDDPKYSS*39DEDLPSKLEAFKKKYMEFDLN EDGGIDIMSLKRMMEKLGVPKTHLELKKLIMEVSSGPGETFSYSDFLKMMLGKRSAILKM ILMYEEKAREQEKPTGLPAKKAISELP
Predicted Disorder Regions	1-45, 80-82, 114-119, 132-147
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	Overexpression of AIF-1 causes enhanced production of cell cycle proteins and G-CSF, both of which are responsible for the proliferation of VSMCs.Site-directed mutagenesis in the EF region of AIF-1 causes loss of its calcium-binding activity, which makes AIF-1 incapable of enhancing proliferation,migration, and G-CSF expression.
Bibliography	1.Sikora M, Kopeć B, Piotrowska K, Pawlik A. Role of allograft inflammatory factor-1 in pathogenesis of diseases. Immunol Lett. 2020 Feb;218:1-4. doi: 10.1016/j.imlet.2019.12.002. Epub 2019 Dec 9. PMID: 31830499. 2.Autieri MV, Kelemen SE, Wendt KW. AIF-1 is an actin –polimerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration. Circ Res 2003;92:1107-1114.