Primary Information |
|---|
| BoMiProt ID | Bomi3797 |
|---|
| Protein Name | Aldehyde oxidase 1/Azaheterocycle hydroxylase 1 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | P48034 |
|---|
| Milk Fraction | Exosomes |
|---|
| Ref Sequence ID | NP_788841.1 |
|---|
| Aminoacid Length | 1339 |
|---|
| Molecular Weight | 147611 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | AOX1 |
|---|
| Gene ID | 338074 |
|---|
| Protein Existence Status | Reviewed |
|---|
Secondary Information |
|---|
| Presence in other biological fluids/tissue/cells | liver, lungs,spleen,kindey, eye, testis, duodenum, esophagus and thymus. |
|---|
| Protein Function | Aldehyde oxidase 1 (AOX1) is involved in the detoxification of a variety of aldehydes and nitrogenous heterocyclic compounds. |
|---|
| Biochemical Properties | molybdenum enzyme,a homodimeric molybdenum cofactor (Moco)‐containing protein with a molecular mass of 300 kDa (2 × 150 kDa) |
|---|
| PTMs | Phosphorylation at Ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P48034|AOXA_BOVIN Aldehyde oxidase 1 OS=Bos taurus OX=9913 GN=AOX1 PE=1 SV=2
MEGGSELLFYVNGRKVTEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYN
PITKKIRHYPANACLTPICSLYGAAVTTVEGIGSTKTRIHPVQERIAKCHGTQCGFCTPG
MVMSLYTLLRNHPEPTLTQLNDALGGNLCRCTGYRPIINACKTFCKTSGCCQSKENGVCC
LDQGMNGLPEFEEGNETSLKLFSEEEFLPLDPTQELIFPPELMTMAEKKTQKTRIFGSDR
MTWISPVTLKELLEAKVKYPQAPVVMGNTSVGPDMKFKGIFHPVIISPDRIEELSVVNYT
DNGLTLGAAVSLAEVKDILANVTRKLPEEKTQMYHALLKHLETLAGPQIRNMASLGGHIV
SRHPDSDLNPLLAVGNCTLNLLSKEGRRQIPLNEQFLRKCPSADLKPEEILISVNIPYSR
KWEFVSAFRQAQRQQNALAIVNSGMRVCFGKGDGIIRELSIAYGGVGPTTILANNSCQKL
IGRPWNEEMLDAACRLILDEVSLPGSAPGGRVEFKRTLIVSFLFKFYLEVSQILKGMDLV
HYPSLASKYESALEDLHSRHYWSTLKYQNADLKQLSQDPIGHPIMHLSGIKHATGEAIYC
DDMPVVDRELFLTFVTSSRAHAKIVSIDVSAALSLPGVVDILTGEHLPGINTTFGFLTDA
DQLLSTDEVSCVGQLVCAVIADSEVQARRAAQQVKIVYQDLEPVILTIEEAIQNKSFFEP
ERKLEYGNVDEAFKMVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDREIDVYVSAQFPK
YIQDITASVLKVSANKVMCHVKRVGGAFGGKVTKTGVLAAITAFAANKHGRPVRCILERG
EDILITGGRHPYLGKYKAGFMNDGRILALDMEHYNNAGAFLDESLFVIEMGLLKLENAYK
FPNLRCRGWACRTNLPSNTALRGFGFPQAGLITEACITEVAAKCGLPPEKVRMINMYKEI
DQTPYKQEINTKNLTQCWKECMATSSYTLRKAAVEKFNSENYWKKKGLAMVPLKYPIGLG
SVAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPLS*1069SIHLRGTSTET
IPNTNPSGGSVVADLNGLAVKDACQTLLKRLKPIISKNPKGTWKDWAQAAFNESISLSAT
GYFRGYESNINWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGYSINPAL
DVGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPNQYKIPAICDIPMELHISFLPPSENS
NTLYSSKGLGESGIFLGCSVFFAIHDAIRAARQERGLPGPLRLNSPLTPEKIRMACEDKF
TKMIPRDEPGSYVPWSVPI
|
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | high expression of AOX1 promoted proliferation and invasion and inhibited apoptosis via reactive oxygen species (ROS) production. |
|---|
| Bibliography | 1.Zhang W, Chai W, Zhu Z, Li X. Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133. Int Immunopharmacol. 2020 Aug;85:106618. doi: 10.1016/j.intimp.2020.106618. Epub 2020 May 26. PMID: 32470878. |
|---|
