Primary Information |
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| BoMiProt ID | Bomi3784 |
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| Protein Name | Alanine aminotransferase 1(ALT1)/Glutamate pyruvate transaminase 1/GPT 1/Glutamic--alanine transaminase 1/Glutamic--pyruvic transaminase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A4IFH5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001077209.1 |
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| Aminoacid Length | 496 |
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| Molecular Weight | 55275 |
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| FASTA Sequence |
Download |
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| Gene Name | GPT/GPT1 |
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| Gene ID | 539188 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | This protein plays an essential role in starch synthesis in developing seeds that are exposed to low concentrations of oxygen. |
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| Biochemical Properties | OsAlaAT1 is localized in the cytosol and has aminotransferase enzyme activity. AlaAT catalyzes the interconversion of pyruvate to alanine, and this pathway is activated under low-oxygen conditions. |
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| PTMs | Acetylation at Ala,Phosphorylation at Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A4IFH5|ALAT1_BOVIN Alanine aminotransferase 1 OS=Bos taurus OX=9913 GN=GPT PE=2 SV=1
MALRAGEHSQEAANGLKEKVLTLDS*22MNPYVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGDAQAMGQIPITFPRQVLALCVHPDLLNSPDFPDDAKRRAERILQACGGHSL
GAYSISAGVQMIREDVARYIERRDGGIPADPNNIFLSTGASDAIVTVLKLLVTGEGRTRT
GVLIPIPQYPLYSAALAEFNAVQVDYYLDEERAWALDVAELRRALRQARDHCRPRALCVI
NPGNPTGQVQTRECIEDVIRFAYEEKLFLLADEVYQDNVYAESSQFHSFKKVLTEMGPPY
AAQQELASFHSISKGYMGECGFRGGYVEVVNMDAAVKQQMQKLRSVRLCPPTPGQVLLDV
AVSPPAPSDPSFPRFQAERRAVLAELAAKAKLTEQVFNEAPGIRCNPVQGAMYSFPRVQL
PPRAVQRAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPMEKLRPL
LEKLSQFHAKFTREYS
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation at Thr-9 by ALPK1 gives rise to the formation of an intermolecular binding between the FHA domain and also promotes TIFA oligomerization and TIFA-mediated NF-kappa-B activation. |
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| Additional Comments | The osalaat1 mutant has less amylose and its amylopectin is structurally altered. |
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| Bibliography | Yang J, Kim SR, Lee SK, Choi H, Jeon JS, An G. Alanine aminotransferase 1 (OsAlaAT1) plays an essential role in the regulation of starch storage in rice endosperm. Plant Sci. 2015 Nov;240:79-89. doi: 10.1016/j.plantsci.2015.07.027. Epub 2015 Aug 3. PMID: 26475189. |
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