Search by BoMiProt ID - Bomi377

Primary Information

BoMiProt ID Bomi377
Protein Name Ubiquitin-fold modifier 1
Organism Bos taurus
Uniprot IDQ2KJG2
Milk FractionExosome
Ref Sequence ID NP_001039779.1
Aminoacid Length 85
Molecular Weight 9168
FASTA Sequence Download
Gene Name UFM1
Gene ID 530547
Protein Existence Status Reviewed: Protein inferred from homology

Secondary Information

Presence in other biological fluids/tissue/cells ocalized in both the nucleus and the cytoplasm
Protein Function Ubiquitin-like protein; small Ubl modifier; Ufm1 conjugation to its target proteins, a process termed as ufmylation, is accomplished in multi-step biochemical reactions that are catalyzed by a set of Ufm1-specific enzymes
Biochemical Properties Expressed in human cells as a precursor with a C-terminal Ser-Cys dipeptide extension, which needs to be processed by UFSPs prior to conjugation to target proteins; Matured UFM1 has a single glycine residue at the C-terminus, which also is required for conjugation to its target proteins, unlike ubiquitin and most other ubiquitin-like proteins, such as SUMO and NEDD8, which have a conserved C-terminal di-glycine; adopts an ubiquitin-like α + β fold with ordered β−β−α−β−β−α−β secondary structure along the sequence; a special feature in UFM1 structure is the absence of the cluster of the acidic residues in the α1 surface, which is displayed by ubiquitin; employs the uncharged surface for binding to its putative partners
Significance in milk play an important role during the inflammatory response and thereby acts as a potential therapeutic target for bovine mastitis
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Li, C. et al. (2019) ‘UFL1 Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4/NF- κ B Pathway in Bovine Mammary Epithelial Cells’, Oxidative Medicine and Cellular Longevity. Hindawi, 2019, pp. 1–17. doi: 10.1155/2019/6505373.