Primary Information |
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| BoMiProt ID | Bomi3745 |
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| Protein Name | Adseverin/Scinderin |
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| Organism | Bos taurus |
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| Uniprot ID | Q28046 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776602.1 |
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| Aminoacid Length | 715 |
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| Molecular Weight | 80578 |
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| FASTA Sequence |
Download |
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| Gene Name | SCIN |
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| Gene ID | 281478 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells.Adseverin has a crucial role in osteoclastogenesis by regulating NFATc1. |
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| Biochemical Properties | Adseverin contains six gelsolin-like (G) domains, three actin binding sites and two calcium binding sites with different affinities. |
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| Significance in milk | Role in bone development |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q28046|SCIN_BOVIN Scinderin OS=Bos taurus OX=9913 GN=SCIN PE=1 SV=1
MAQGLYHEEFARAGKRAGLQVWRIEKLELVPVPESAYGNFYVGDAYLVLHTTQASRGFTY
RLHFWLGKECTQDESTAAAIFTVQMDDYLGGKPVQNRELQGY*102ESTDFVGYFKGGLKYKAG
GVASGLNHVLTNDLTAQRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGS
SCNKYERLKASQVAIGIRDNERKGRAQLIVVEEGSEPSELTKVLGEKPKLRDGEDDDDIK
ADITNRKMAKLYMVSDASGSMKVSLVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKD
ANPQERKAAMKTAEEFLQQMNYSTNTQIQVLPEGGETPIFKQFFKDWRDRDQSDGFGKVY
VTEKVAHVKQIPFDASKLHSSPQMAAQHHVVDDGSGKVQIWRVENNGRVEIDRNSYGEFY
GGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPA
HLLSLFKDKPLIIYKNGTSKKEGQAPAPPIRLFQVRRNLASITRIMEVDVDANSLNSNDV
FVLKLRQNNGYIWIGKGSTQEEEKGAEYVASVLKCKTSTIQEGKEPEEFWNSLGGKKDY*502Q
TSPLLESQAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGK
DANEVEKSESLKSAKIYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis. |
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| Bibliography | 1.Song, M. K., Lee, Z. H., & Kim, H. H. (2015). Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1. Experimental & molecular medicine, 47(12), e199. https://doi.org/10.1038/emm.2015.94 |
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