Search by BoMiProt ID - Bomi3741

Primary Information

BoMiProt ID Bomi3741
Protein Name ADP-ribosylation factor-like protein 4D
Organism Bos taurus
Uniprot IDQ0VC18
Milk FractionWhey,MFGM
Ref Sequence ID NP_001069603.1
Aminoacid Length 200
Molecular Weight 22126
FASTA Sequence Download
Gene Name ARL4D
Gene ID 538936
Protein Existence Status Reviewed

Secondary Information

Protein Function small GTPases ,role in cell morphology, cell migration, and actin cytoskeleton remodeling. Arl4D promotes the recruitment of EB1 to the centrosome and regulates MT nucleation.ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 2-6, 188-200
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs N-terminal myristoylation of ARL4D was required for its localization to mitochondria.
Additional Comments Many centrosomal defects are due to mutation of this gene.
Bibliography 1.Lin SJ, Huang CF, Wu TS, Li CC, Lee FS. Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth. Mol Biol Cell. 2020 Oct 1;31(21):2348-2362. doi: 10.1091/mbc.E18-10-0611. Epub 2020 Aug 5. PMID: 32755434; PMCID: PMC7851962. 2.Li CC, Chiang TC, Wu TS, Pacheco-Rodriguez G, Moss J, Lee FJ. ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Mol Biol Cell. 2007 Nov;18(11):4420-37. doi: 10.1091/mbc.e07-02-0149. Epub 2007 Sep 5. PMID: 17804820; PMCID: PMC2043562.