Primary Information |
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| BoMiProt ID | Bomi3741 |
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| Protein Name | ADP-ribosylation factor-like protein 4D |
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| Organism | Bos taurus |
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| Uniprot ID | Q0VC18 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001069603.1 |
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| Aminoacid Length | 200 |
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| Molecular Weight | 22126 |
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| FASTA Sequence |
Download |
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| Gene Name | ARL4D |
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| Gene ID | 538936 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | small GTPases ,role in cell morphology, cell migration, and actin cytoskeleton remodeling. Arl4D promotes the recruitment of EB1 to the centrosome and regulates MT nucleation.ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 2-6, 188-200 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | N-terminal myristoylation of ARL4D was required for its localization to mitochondria. |
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| Additional Comments | Many centrosomal defects are due to mutation of this gene. |
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| Bibliography | 1.Lin SJ, Huang CF, Wu TS, Li CC, Lee FS. Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth. Mol Biol Cell. 2020 Oct 1;31(21):2348-2362. doi: 10.1091/mbc.E18-10-0611. Epub 2020 Aug 5. PMID: 32755434; PMCID: PMC7851962. 2.Li CC, Chiang TC, Wu TS, Pacheco-Rodriguez G, Moss J, Lee FJ. ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Mol Biol Cell. 2007 Nov;18(11):4420-37. doi: 10.1091/mbc.e07-02-0149. Epub 2007 Sep 5. PMID: 17804820; PMCID: PMC2043562. |
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