Primary Information
BoMiProt ID	Bomi3734
Protein Name	ADP-ribose glycohydrolase ARH3/ADP-ribosylhydrolase 3/O-acetyl-ADP-ribose deacetylase ARH3/Poly(ADP-ribose) glycohydrolase ARH3/[Protein ADP-ribosylarginine] hydrolase-like protein 2/[Protein ADP-ribosylserine] hydrolase
Organism	Bos taurus
Uniprot ID	Q3SYV9
Milk Fraction	whey
Ref Sequence ID	NP_001030417.1
Aminoacid Length	365
Molecular Weight	39221
FASTA Sequence	Download
Gene Name	ADPRS/ADPRHL2
Gene ID	521650
Protein Existence Status	Reviewed
Secondary Information
Protein Function	ADP-ribose glycohydrolase ARH3 hydrolyzes the scissile α-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates. Proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose act as its substrates.It also plays role in controlling DNA damage as it behaves as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	(54-74)
DisProt Annotation
TM Helix Prediction	no TM helices
Bibliography	Hanzlikova, H., Prokhorova, E., Krejcikova, K., Cihlarova, Z., Kalasova, I., Kubovciak, J., Sachova, J., Hailstone, R., Brazina, J., Ghosh, S., Cirak, S., Gleeson, J. G., Ahel, I., & Caldecott, K. W. (2020). Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature communications, 11(1), 3391. https://doi.org/10.1038/s41467-020-17069-9