Primary Information
BoMiProt ID	Bomi3733
Protein Name	ADP-dependent glucokinase
Organism	Bos taurus
Uniprot ID	A2VE47
Milk Fraction	Whey
Ref Sequence ID	NP_001075907.1
Aminoacid Length	497
Molecular Weight	54086
FASTA Sequence	Download
Gene Name	ADPGK
Gene ID	518158
Protein Existence Status	reviewed
Secondary Information
Protein Function	It plays a critical role in T cell receptor activation-induced remodeling of energy metabolism
Biochemical Properties	ADPGK co-localizes with ER markers calreticulin and IP3R1 (inositol-3-phosphate-receptor) as well as with the rough ER marker SRPRβ (signal recognition particle receptor). Te frst 21 amino acids of the ADPGK precursor protein is the ER-targeting sequence, whereas a highly hydrophobic amino acid stretch at position 80–100 aa was predicted to be a membrane spanning region5 , suggesting an active site protruding towards the cytosol.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	1TMH; (7-25)
Additional Comments	ADP-dependent glucokinase (ADPGK) as a novel glucose sensor and a potential onco-target in specifically high-proliferating cells in Burkitt's lymphoma (BL)
Bibliography	1.Imle R, Wang BT, Stützenberger N, Birkenhagen J, Tandon A, Carl M, Himmelreich N, Thiel C, Gröne HJ, Poschet G, Völkers M, Gülow K, Schröder A, Carillo S, Mittermayr S, Bones J, Kamiński MM, Kölker S, Sauer SW. ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing. Sci Rep. 2019 Oct 3;9(1):14248. doi: 10.1038/s41598-019-50566-6. PMID: 31582762; PMCID: PMC6776650. 2.Tandon A, Birkenhagen J, Nagalla D, Kölker S, Sauer SW. ADP-dependent glucokinase as a novel onco-target for haematological malignancies. Sci Rep. 2020 Aug 12;10(1):13584. doi: 10.1038/s41598-020-70014-0. PMID: 32788680; PMCID: PMC7423609.