Primary Information |
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| BoMiProt ID | Bomi372 |
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| Protein Name | Heat shock protein 75 kDa, mitochondrial |
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| Organism | Bos taurus |
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| Uniprot ID | Q2TBI4 |
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| Milk Fraction | MFGM |
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| Ref Sequence ID | NP_001033764.1 |
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| Aminoacid Length | 703 |
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| Molecular Weight | 79381 |
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| FASTA Sequence |
Download |
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| Gene Name | TRAP1 |
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| Gene ID | 514472 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | The highest
expression levels of TRAF1 can be found in spleen, lung,
and testis |
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| Protein Function | Also known as tumor necrosis factor receptor associated protein1 (TRAF1) is a cytoplasmic adapter proteins that can interact
directly with the intracellular domains of cell surface
receptors; capable of initiating programmed cell death; initiate signal transduction pathways
that culminate in caspase activation and apoptosis; play an important role in
modulating an early step in receptor-induced activation
of NF-kB |
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| Biochemical Properties | localized in the soluble
fraction of the cytoplasm of cells; trimerizes upon
binding to the TNF trimer inducing association of
its intracellular death domain; death domain is a protein interaction motif
involved in homo- and hetero-association and is essential for the transduction of
cytotoxic signals; death
domainsself-associate and form large molecular
mass aggregates at physiological pH; |
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| Significance in milk | heat stress proteins in mamary gland |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | sensitive to heat stress and mainly responsible for mammary cell protection from heat stress |
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| Bibliography | 1. Sukits, S. F. et al. (2001) ‘Solution structure of the tumor necrosis factor receptor-1 death domain’, Journal of Molecular Biology, 310(4), pp. 895–906. doi: 10.1006/jmbi.2001.4790.
2. Rothe, M. et al. (1994) ‘A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor’, Cell, 78(4), pp. 681–692. doi: 10.1016/0092-8674(94)90532-0.
3. Cao, Z. et al. (1996) ‘TRAF6 is a signal transducer for interleukin-1’, Nature, 383(6599), pp. 443–446. doi: 10.1038/383443a0.
4. Kuhné, M. R. et al. (1997) ‘Assembly and regulation of the CD40 receptor complex in human B cells.’, The Journal of experimental medicine, 186(2), pp. 337–42. doi: 10.1084/jem.186.2.337.
5. Rothe, M. et al. (1995) ‘TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40’, Science, 269(5229), pp. 1424–1427. doi: 10.1126/science.7544915. |
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