Primary Information |
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| BoMiProt ID | Bomi3690 |
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| Protein Name | Adenosylhomocysteinase 3/IP(3)Rs binding protein released with IP(3) 2/Long-IRBIT |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLP2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001094613.1 |
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| Aminoacid Length | 611 |
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| Molecular Weight | 66774 |
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| FASTA Sequence |
Download |
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| Gene Name | AHCYL2 |
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| Gene ID | 532836 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | It may be involved in regulation of the sodium-bicarbonate cotransporter SLC4A4 activity and Mg2+-sensitivity. |
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| Biochemical Properties | Involved in L-homocysteine biosynthesis.Catalyses the following reaction, H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine |
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| PTMs | Phosphorylation, Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLP2|SAHH3_BOVIN Adenosylhomocysteinase 3 OS=Bos taurus OX=9913 GN=AHCYL2 PE=1 SV=1
MSVQVVSAAAAAKVPEVELKDLSPSEAEPQLGLSTAAVSAMAPPAGGGDPEAPAPAAERP
PAPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVS*107PDGTVTEAPRTVK
KQIQFADQKQEFNKRPTKIGRRSLSRSIS*149QSS*152TDS*155YSS*158AASYTDSSDDETSPRDKQQKNSKGNSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTA
VLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVE
GWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVN
DSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYV
TEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGH
SNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIILLAEGRLLNLSCSTVPTFVLSITA
TTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNK
NGPFKPNYYRY
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| Predicted Disorder Regions | (1-94), (109-183) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylated during neuronal differentiation at the LISN domain. |
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| Bibliography | Yamaguchi, S., & Ishikawa, T. (2014). AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B. FEBS letters, 588(5), 672–677. https://doi.org/10.1016/j.febslet.2013.12.036 |
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