Primary Information
BoMiProt ID	Bomi3653
Protein Name	Acyl-coenzyme A thioesterase 9, mitochondrial/ Acyl-CoA thioesterase 9/Acyl-CoA thioester hydrolase 9
Organism	Bos taurus
Uniprot ID	Q3SWX2
Milk Fraction	Whey
Ref Sequence ID	NP_001029732.1
Aminoacid Length	437
Molecular Weight	49853
FASTA Sequence	Download
Gene Name	ACOT9
Gene ID	527845
Protein Existence Status	reviewed
Secondary Information
Protein Function	traffics mitochondrial short-chain fatty acids towards de novo lipogenesis and glucose production in the liver. It also regulates neuronal fatty acid metabolism to prevent neurotoxicity.
Biochemical Properties	Hepatic Acot9 localized to the inner mitochondrial membrane, where it deactivated short-chain but not long-chain fatty acyl-CoA. This unique localization and activity of Acot9 directed acetyl-CoA away from protein lysine acetylation and toward the citric acid (TCA) cycle.
Significance in milk	Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cells during secretory activation
PTMs	Acetylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Steensels S, Qiao J, Zhang Y, Maner-Smith KM, Kika N, Holman CD, Corey KE, Bracken WC, Ortlund EA, Ersoy BA. Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver. Hepatology. 2020 Sep;72(3):857-872. doi: 10.1002/hep.31409. PMID: 32498134. 2.Ellis JM, Wong GW, Wolfgang MJ. Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol. 2013 May;33(9):1869-82. doi: 10.1128/MCB.01548-12. Epub 2013 Mar 4. PMID: 23459938; PMCID: PMC3624175.