Primary Information |
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| BoMiProt ID | Bomi3645 |
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| Protein Name | Acyl-CoA synthetase short-chain family member 3, mitochondrial |
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| Organism | Bos taurus |
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| Uniprot ID | A7MB45 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095607.1 |
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| Aminoacid Length | 686 |
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| Molecular Weight | 74805 |
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| FASTA Sequence |
Download |
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| Gene Name | ACSS3 |
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| Gene ID | 531552 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids.Restoration of ACSS3 expression in PCa cells significantly reduced LD deposits, thus promoting apoptosis by increasing endoplasmic reticulum (ER) stress. |
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| Biochemical Properties | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate |
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| Significance in milk | bovine milk fatty acid synthesis |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, Yang X, Chen K. ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. Theranostics. 2021 Jan 1;11(2):841-860. doi: 10.7150/thno.49384. PMID: 33391508; PMCID: PMC7738848. |
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